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EIF2AK2 — RAX

Text-mined interactions from Literome

Ruvolo et al., J Biol Chem 2001 : Since ceramide potently promotes RAX and eukaryotic initiation factor-2alpha phosphorylation, a possible role for ceramide in this process may involve the activation of PKR by RAX
Bennett et al., J Biol Chem 2004 : Serine 18 phosphorylation of RAX , the PKR activator, is required for PKR activation and consequent translation inhibition ... Previous reports demonstrate that following stress, RAX/PACT associates with and activates PKR resulting in eIF2alpha phosphorylation, consequent translation inhibition, and cell death via apoptosis ... We propose that the ability of RAX to activate PKR is regulated by a sequential mechanism featuring RAX association with PKR, RAX phosphorylation at serine 18, and activation of PKR
Chen et al., J Biol Chem 2006 : In contrast, overexpression of a mutant ( S18A ) RAX inhibited ethanol mediated PKR/eIF2alpha activation
Bennett et al., Blood 2006 (Inflammation...) : Now we report that RAX , the only known cellular activator for PKR, initiates PKR activation in response to a broad range of stresses including serum deprivation, cytotoxic cytokine or chemotherapy treatment, or viral infection ... Furthermore, RAX ( S18A ) expression in Fanconi anemia complementation group C-null MEF cells not only prevents PKR activation but also blocks hypersensitivity to IFNgamma/TNFalpha or mitomycin C that results in enhanced apoptosis
Bennett et al., Cell cycle (Georgetown, Tex.) 2012 : Cellular stresses, including growth factor deprivation, inflammatory cytokines or viral infection promote RAX/PACT dependent activation of the double stranded RNA dependent protein kinase, PKR , to phosphorylate eIF2a, resulting in translation inhibition and apoptosis