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IRF6 — SERPING1
Text-mined interactions from Literome
Liu et al., J Immunol 2003
(Disease Models, Animal...) :
Both forms of
C1INH blocked the LPS binding protein dependent binding of Salmonella typhimurium
LPS to the murine macrophage cell line, RAW 264.7, and suppressed LPS induced TNF-alpha mRNA expression
Liu et al., Blood 2005
(Shock, Septic) :
As illustrated by laser scanning confocal microscopy,
C1INH completely
blocked the binding of fluorescein isothiocyanate ( FITC )
-LPS to human umbilical vein endothelial cells ( HUVECs )
Liu et al., Infect Immun 2005
:
The
C1INH mutants that did not bind to LPS also did not
suppress LPS binding or LPS induced up-regulation of tumor necrosis factor alpha mRNA expression in RAW 264.7 macrophages
Landsem et al., Clin Exp Immunol 2013
(Sepsis) :
C1-INH ( 1·25-5 mg/ml )
reduced both
LPS- and E.?coli induced coagulation, measured as a reduction of PTF1·2 in plasma, efficiently and dose-dependently ( P < 0·05 )