◀ Back to TP53
MYCN — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chen et al., Cancer Res 2010
(Brain Neoplasms...) :
Based on observations of nuclear p53 accumulation in neuroblastoma, we hypothesized that
MYCN may
regulate p53 in this setting ... We concluded that
MYCN transcriptionally
upregulates p53 in neuroblastoma and uses p53 to mediate a key mechanism of apoptosis
He et al., Cell cycle (Georgetown, Tex.) 2011
(Neuroblastoma) :
Previous studies show that the MYCN and MDM2-p53 signal pathways are mutually regulated :
MYCN stimulates MDM2 and
p53 transcription, whereas MDM2 stabilizes MYCN mRNA and induces its translation ... In MYCN amplified neuroblastoma cells, enforced expression of MDM2 further enhanced
MYCN expression, yet no
p53 inhibition was observed by MDM2 due to upregulation of MYCN that stimulated p53 transcription
Petroni et al., Frontiers in oncology 2012
:
Indeed
MYCN induces
p53 and MDM2 transcription, and, by evoking a DNA damage response ( DDR ), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Protein Kinase 2 ( HIPK2 )