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CD4 — IL16
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
IL16
—
CD4
(direct interaction, pull down)
Cruikshank et al., Proc Natl Acad Sci U S A 1994*
-
IRef Dip Interaction:
IL16
—
CD4
(physical association, experimental interaction detection)
Cruikshank et al., Proc Natl Acad Sci U S A 1994*
-
IRef Hprd Interaction:
IL16
—
CD4
(in vivo)
Rand et al., J Exp Med 1991*, Cruikshank et al., Proc Natl Acad Sci U S A 1994*
-
IRef Innatedb Interaction:
IL16
—
CD4
(unknown, -)
Cruikshank et al., Proc Natl Acad Sci U S A 1994*
-
IRef Ophid Interaction:
IL16
—
CD4
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
IL16
—
CD4
(aggregation, confirmational text mining)
Cruikshank et al., Proc Natl Acad Sci U S A 1994*
Text-mined interactions from Literome
Mashikian et al., J Immunol 1999
:
Reciprocal desensitization of CCR5 and
CD4 is
mediated by
IL-16 and macrophage-inflammatory protein-1 beta, respectively
Mathy et al., J Immunol 2000
:
Cutting edge :
CD4 is not
required for the functional activity of
IL-16
Kitchen et al., Blood 2002
:
IL-16 mediated ligation of
CD4 expressed on CD8 T cells was found to induce an intracellular signal that directs migration of these cells in vitro
Pepe et al., Curr Pharm Des 2006
:
This Th1 polarizing activity is mediated by
interleukin-12 released by infected CDs in the
presence of
CD4 ( + ) cells
Ariga et al., Immunology 2007
:
Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive
CD4 ( + ) T cells
induces transient T-bet expression,
interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Liu et al., Cytokine 2007
:
IL-16 signaling specifically
induces STAT6 activation through
CD4 ... To gain a better understanding of how the biologic activities of
IL-16 are
regulated following receptor engagement (
CD4 ) we have analyzed the activation state of numerous STAT proteins in primary human peripheral blood mononuclear cells ( PBMCs ) and the human monocytic cell line THP-1 following IL-16 stimulation
Yadav et al., J Immunotoxicol 2010
:
As
IL-16 ( at locally high levels ) can
induce CD4 ( + ) cell death via apoptosis, this potential outcome among the A549 cells was also evaluated using TUNEL and changes in expression of caspase-3 and the pro-apoptotic and anti-apoptotic proteins of Bcl-2 family
Fenster et al., Neurosci Lett 2010
:
The
role of
CD4 dependent signaling in
interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons
Vandergeeten et al., Blood 2013
(HIV Infections) :
When administered to HIV infected subjects receiving suppressive ART,
interleukin-7 (IL-7)
increases the number of
CD4 ( + ) T cells by promoting their survival and proliferation
Cruikshank et al., J Immunol 1996
:
In addition,
IL-16 had no effect on surface expression of CD3 or
CD4
Center et al., Int J Biochem Cell Biol 1997
(Asthma) :
IL-16 requires the expression of
CD4 for its functions, which include induction of chemotaxis, interleukin-2 receptor and HLA-DR expression, reversible inhibition of TcR/CD3 dependent activation and induction of a repressor of HIV-1 transcription
Parada et al., J Immunol 1998
:
IL-16 , in a
CD4 dependent manner, induces high affinity IL-2R ( CD25 ) selectively on CD4+ T cells ...
IL-16 increased
CD4+ T cell IL-2Ralpha and beta expression, but had no effect on expression of IL-2Rgamma
Suzuki et al., J Virol 1999
:
Among them,
interleukin-12 (IL-12) and IL-4
induce naive
CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively