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MYC — PLD2
Text-mined interactions from Literome
Chen et al., Oncogene 2003
(Adenocarcinoma...) :
Elevated
PLD activity in MCF-7 cells also caused rapamycin resistance for S6 kinase phosphorylation and serum
induced Myc expression
Rodrik et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Stable elevated expression of
PLD2 also
increased Myc expression and provided a Myc dependent survival signal in the absence of E2
Rodrik et al., FEBS Lett 2006
(Breast Neoplasms) :
We report here that estrogen- and
PLD induced increases in
Myc expression are due to reduced turnover of Myc protein ... Estrogen and
PLD suppressed phosphorylation of
Myc at Thr58 -- a site that targets Myc for degradation by the proteasome