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ANGPT2 — SOD2
Text-mined interactions from Literome
Chabrashvili et al., Am J Physiol Regul Integr Comp Physiol 2003
(Body Weight) :
Compared to Veh,
ANG II significantly ( P < 0.005 )
increased the renal cortical mRNA expression of p22phox ( twofold ), Nox-1 ( 2.6-fold ), and
Mn-SOD ( 1.5-fold ) and decreased expression of Nox-4 ( 2.1-fold ) and extracellular (EC)-SOD ( 2.1-fold )
Manea et al., J Cell Mol Med 2004
(Diabetes Mellitus) :
The presence of AGE-Lys or
Ang II induced the increase of
SOD activity
Yin et al., Am J Physiol Cell Physiol 2010
:
Mn-SOD overexpression also
inhibited ANG II-induced activation of Ca ( 2+ ) /calmodulin kinase II, a redox-sensitive protein known to modulate I ( Kv )
Bhatia et al., Am J Physiol Regul Integr Comp Physiol 2012
(Hypertension) :
ANG II infusion
increased plasma
superoxide dismutase activity only in female SHR ( 76 ± 9 vs. 190 ± 7 Units·ml(-1)·mg ( -1 ), P < 0.05 ) ; however, cortical antioxidant capacity was unchanged by ANG II in either sex
Zafari et al., Hypertension 1998
(Hypertrophy) :
Neither
superoxide dismutase activity nor catalase activity was
affected by
Ang II ; the SOD present in VSMCs is sufficient to metabolize Ang II-stimulated superoxide to H2O2, which accumulates more rapidly than it is degraded by catalase