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HGF — IL8

Text-mined interactions from Literome

Sugawara et al., Infect Immun 1999 : While Bacillus subtilis LTA had an IL-8 inducing effect on CD14 ( high ) HGF which was considerably weaker than that of LPS, Streptococcus sanguis and Streptococcus mutans LTAs had practically no effect on the cells
Dong et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : Hepatocyte growth factor/scatter factor induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma ... HGF induced a significant dose dependent increase in IL-8 and/or VEGF cytokine production in eight HNSCC lines tested, which is not observed in normal keratinocytes ... In addition, HGF increased mRNA expression of IL-8 in 3 of 6 and VEGF in 5 of 6 HNSCC lines ... Inhibitors of MEK ( U0126 ) and PI3K ( LY294002 ) blocked p42/p44 ( erk ) and Akt, respectively, and partially blocked HGF induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A
Matsumoto et al., Biochem Biophys Res Commun 1992 : Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts
Takami et al., Biochem Biophys Res Commun 2004 : HGF production is induced by the activation of protein kinase A and protein kinase C-mediated pathways, interleukin (IL)-1 , tumor necrosis factor (TNF)-alpha, and epidermal growth factor (EGF) in mesenchymal cells
Yokoyama et al., Oral Microbiol Immunol 2005 : Stimulation of HGF with VEGF resulted in production of IL-6 and IL-8 in a dose dependent manner
Grygas et al., In Vitro Cell Dev Biol Anim 2007 : Hepatocyte growth factor enhances IL-1beta stimulated IL-8 secretion by Caco-2 epithelial cells ... In this report, we have examined the effect of HGF on IL-1 induced secretion of IL-8 by the Caco-2 colonic epithelial cell line ... HGF stimulation alone had no effect on the secretion of IL-8 by the Caco-2 cells
Knowles et al., Clin Cancer Res 2009 (Carcinoma, Squamous Cell...) : c-Met TKIs blocked HGF induced signaling, interleukin-8 release, and wound healing
Schmeding et al., Transplantation 2010 (Fatty Liver) : Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA ( interleukin-1 , interleukin-6, hypoxia induced factor-1 alpha, vascular endothelial growth factor, and hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Chen et al., Stem Cells Dev 2011 (Acute Kidney Injury...) : Real-time polymerase chain reaction result showed that HGF-hucMSCs also inhibited caspase-3 and interleukin-1ß mRNA expression in injured renal tissues
Unger et al., In Vitro Cell Dev Biol Anim 2011 : Previously, we have shown that hepatocyte growth factor (HGF) could significantly enhance IL-1 stimulated IL-8 secretion by the Caco-2 colonic epithelial cell line, yet HGF, by itself, did not stimulate IL-8 secretion
Kaga et al., Vascul Pharmacol 2012 (Inflammation) : In addition, bFGF, but not HGF or VEGF, significantly activated an essential transcription factor for inflammation, NF?B, and gene expression of its downstream inflammation related cytokines ( IL-8 and MCP-1 ) in VSMCs, accompanied by an increase in the vascular permeability in the rat paper disc model
Wang et al., Hum Gene Ther 2013 (Disease Models, Animal...) : MSCs-HGF could reduce secretion and expression of proinflammatory cytokines, including tumor necrosis factor-a, interferon-?, interleukin (IL)-6, and intercellular adhesion molecule-1, and increase the expression of antiinflammatory cytokine IL-10
Wells et al., Am J Physiol Cell Physiol 2013 : We found that HGF stimulation caused MDCK cells in 3D culture to decrease the expression of IL-8 at both the mRNA and protein levels
Lee et al., Oncol Res 2013 (Adenocarcinoma...) : We investigated the role of HGF induced activation of GRP and Ets-1 transcription factor in expression of the proangiogenic factor IL-8 ... A role for Ets-1 in HGF induced upregulation of IL-8 was determined by knockdown of Ets-1 with Ets-1 sh-RNA and a chromatin immune precipitation assay ... HGF induced expression of Ets-1 and IL-8 was increased more by GRP treatment and inhibited by pretreatment with an ERK 1/2 inhibitor ( PD098059 ) ... HGF induced upregulation of IL-8 was repressed by Ets-1 knockdown ... In conclusion, HGF mediated the GRP induction of IL-8 expression through Ets-1, which thus might serve as a promising target for gastric cancer therapy
Bazin et al., J Immunol 1987 (Ascites...) : The HGF activity was not mediated by interleukin 1 because the two activities could be completely separated by gel filtration
Sugiyama et al., Infect Immun 1996 : Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor ( scatter factor ) in human gingival fibroblasts in culture
Gohda et al., J Cell Physiol 1998 (Leukemia) : Granulocyte colony stimulating factor ( G-CSF ), granulocyte/macrophage colony stimulating factor ( GM-CSF ), interleukin (IL)-5 and IL-6 had no effect on HGF/SF production in the 2 leukemia cell lines
Bamba et al., Biochem Biophys Res Commun 1998 (Peptic Ulcer...) : Among various potential stimulants tested, interleukin-1 beta (IL-1 beta) dramatically increased PGE2 production and significantly stimulated HGF production
Miyazaki et al., Biochem Biophys Res Commun 1998 : Increased hepatocyte growth factor production by aging human fibroblasts mainly due to autocrine stimulation by interleukin-1 ... The increased production of HGF by aging fibroblasts from human embryonic lung tissue is mainly due to autocrine stimulation by interleukin-1