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HMOX1 — SETD2

Text-mined interactions from Literome

Hartsfield et al., Am J Physiol 1999 : Our group has previously demonstrated that the transcription factor hypoxia-inducible factor (HIF)-1 mediates hypoxia induced HO-1 gene transcription and expression in systemic ( aortic ) vascular smooth muscle ( AoVSM ) cells ( P. J. Lee, B. -H. Jiang, B. Y. Chin, N. V. Iyer, J. Alam, G. L. Semenza, and A. M. K. Choi
Ockaili et al., Am J Physiol Heart Circ Physiol 2005 (Myocardial Infarction...) : Thus our data show that HIF-1 activation induces substantial HO-1 expression that is associated with attenuated proinflammatory chemokine production by microvascular endothelium in vitro and in vivo
Loboda et al., Antioxid Redox Signal 2009 : Indeed, HIF-1 mediated downregulation of both IL-8 and HO-1 was associated with both lowered Nrf2 expression and induction of Bach1, a repressor of Nrf2 transcriptional activity ... Accordingly, overexpression of Nrf2 reversed the inhibitory effect of HIF-1 on IL-8 and HO-1 expression
Chan et al., PloS one 2011 (Anoxia...) : At the same time, transcriptional upregulation of heme oxygenase-1 in RVLM by hypoxia-inducible factor-1a (HIF-1a) plays a pro-life role in experimental brain death, and HIF-1a is subject to sumoylation activated by transient cerebral ischemia
Zhang et al., Medicina (Kaunas) 2012 (Anoxia) : HIF-1a may regulate potassium voltage gated channel, shaker related subfamily, member ( 5KCNA5 ), solute carrier family 2 ( facilitated glucose transporter ), member ( 1SLC2A1 ), and heme oxygenase (decycling) 1 ( HMOX1 ) expression through the regulation of membrane potential, glucose metabolism, and anti-inflammation pathways
Lee et al., J Biol Chem 1997 (Anoxia) : A role for HIF-1 in HO-1 gene regulation was established by the following observations : 1 ) HIF-1 specifically bound to an oligonucleotide spanning these sequences, 2 ) mutation of these sequences abolished HIF-1 binding and hypoxia dependent gene activation in VSM cells, 3 ) hypoxia increased HIF-1alpha and HIF-1beta protein levels in VSM cells, and 4 ) hypoxia dependent HO-1 mRNA accumulation was not observed in mutant hepatoma cells lacking HIF-1 DNA binding activity