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MYCN — TMED7

Text-mined interactions from Literome

Matsuo et al., Med Pediatr Oncol 2001 (Neuroblastoma) : To determine whether increased levels of N-MYC could affect the level of p27, we evaluated the expression of p27 in a series of N-MYC transfected cells and found that constitutive overexpression of N-MYC led to a decrease in the steady-state levels of p27 and in p27 bound to G1 cyclin/cdk complexes
Nakamura et al., Cell Death Differ 2003 (Neuroblastoma) : Retinoic acid decreases targeting of p27 for degradation via an N-myc dependent decrease in p27 phosphorylation and an N-myc independent decrease in Skp2 ... N-myc regulates p27 levels through an increase in targeting of p27 to the proteasome via cyclin E kinase dependent phosphorylation of p27 and its ubiquitination ... The decrease in the degradation of p27 in RA-treated cells is due in part to a decrease in the N-myc stimulated phosphorylation of p27