◀ Back to PTPN11

IL6ST — PTPN11

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → SHP2 (PTPN11) (modification, activates) Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: SHP2 (PTPN11) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
  Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database SHP2 signaling: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → SHP2 (PTPN11) (modification, activates) Schaper et al., Biochem J 1998
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: PTPN11 → IL6ST (indirect_complex) Stahl et al., Science 1995*, Symes et al., Curr Biol 1997*, Schaper et al., Biochem J 1998
• Reactome Reaction: PTPN11 → IL6ST (reaction) Stahl et al., Science 1995*, Symes et al., Curr Biol 1997*, Schaper et al., Biochem J 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTPN11 — IL6ST (direct interaction, pull down) Schmitz et al., J Biol Chem 2000
• IRef Biogrid Interaction: PTPN11 — IL6ST (physical association, affinity chromatography technology) Lehmann et al., J Biol Chem 2003*
• IRef Biogrid Interaction: PTPN11 — IL6ST (physical association, affinity chromatography technology) Kim et al., J Biol Chem 1997*
• IRef Biogrid Interaction: PTPN11 — IL6ST (physical association, affinity chromatography technology) Anhuf et al., J Immunol 2000*
• MIPS CORUM LMO4-gp130 complex: LMO4-gp130 complex complex (IL6ST-JAK1-LMO4-PTPN11-SOCS3) Novotny-Diermayr et al., J Biol Chem 2005
• IRef Corum Interaction: Complex of SOCS3-JAK1-IL6ST-LMO4-PTPN11 (association, anti tag coimmunoprecipitation) Novotny-Diermayr et al., J Biol Chem 2005
• IRef Dip Interaction: IL6ST — PTPN11 (physical association, coimmunoprecipitation) Kim et al., J Biol Chem 1997*
• IRef Hprd Interaction: PTPN11 — IL6ST (in vitro) Anhuf et al., J Immunol 2000*, Lehmann et al., J Biol Chem 2003*, Schiemann et al., J Biol Chem 1997*
• IRef Hprd Interaction: PTPN11 — IL6ST (in vivo) Anhuf et al., J Immunol 2000*, Lehmann et al., J Biol Chem 2003*, Schiemann et al., J Biol Chem 1997*
• IRef Ophid Interaction: IL6ST — PTPN11 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ozawa et al., Mol Cell Neurosci 2004 : We demonstrated that STAT3 activation, but not SHP2 activation, is responsible for the CNTF/gp130 signaling that inhibits expression of Rhodopsin and its upstream activator, crx, in the retinal explants derived from P0 mice ( P0 retinal explants ), utilizing STAT3-deficient retina and electroporation of dominant negative form of STAT3 ( STAT3F )
Sands et al., Mol Cell Biol 2006 : Attenuation of SOCS-3 induction in either ECs or SOCS-3-null murine embryonic fibroblasts abolished the inhibitory effect of cAMP, whereas inhibition of SHP-2 , another negative regulator of gp130 , was without effect