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ANGPT2 — KDR

Pathways - manually collected, often from reviews:

• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  

Text-mined interactions from Literome

Taylor et al., Clin Cancer Res 2002 (Neoplasms...) : The increased VEGF of HT-29 was paralleled by a 2-fold ( week 4 ) rise in VEGF receptor flk-1 on vessels as well as increased ang-2/Tie-2
Wulff et al., Reproduction 2003 (Neovascularization, Pathologic...) : It is hypothesized that VEGF/VEGF-R1 and Ang-1/Tie receptor 2 (Tie-2) may regulate trophoblast differentiation and invasion ; VEGF/VEGF-R2 and Ang-1/Tie-2 may promote fetoplacental vascular development and stabilization ; and Ang-2/Tie-2 may be involved in maternal vascular remodelling
Takazawa et al., Kidney Int 2005 (Glomerulonephritis...) : At the early stage ( day 6 ), glomerular expression of VEGF and receptors flk-1 and flt-1 as well as Ang-1, and receptor Tie2 were increased, and glomerular monocyte infiltration and the expression of angiopoietin-2 (Ang-2) , a natural antagonist of Ang-1, were reduced
Kitayama et al., Am J Hypertens 2006 (Disease Models, Animal...) : The increase of flk-1 and flt-1 ( VEGF receptors ) and tie-2 ( Ang1 receptor ) induced by ang II was significantly suppressed by PD123319
Goettsch et al., J Cell Physiol 2008 : Inhibition of VEGFR-2 prevented upregulation of Ang-2 by low flow, but not downregulation of Ang-2 by high flow