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ANGPT2 — PAX2
Text-mined interactions from Literome
Zhang et al., Kidney Int 2004
:
Ang II up-regulated
Pax-2 gene expression via AT2R in IRPTC ... The stimulatory
effect of both
Ang II on
Pax-2 gene expression was blocked by PD123319 ( AT2R inhibitor ), AG 490 ( specific Janus kinase 2 (JAK2) inhibitor ) and genistein ( tyrosine kinase inhibitor ), but not by losartan ( AT1R inhibitor ) ... Our studies suggest that
Ang II stimulates
Pax-2 gene expression in IRPTC via AT2R and the JAK2/signal transducers and activators of transcription ( STAT ) signaling transduction pathway, which may be important in renal repair following injury
Chen et al., Pediatr Nephrol 2008
:
In ex vivo studies,
Ang II stimulated
Pax-2 and N-myc mRNA expression in embryonic kidneys of wild-type mice, but this stimulatory effect was absent in embryonic kidneys of AT(2)R KO mice