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GATA4 — STAT3

Text-mined interactions from Literome

Yao et al., Exp Hematol 2009 : Recently, GATA-1 , a key transcription factor involved in hematopoietic cell development, was shown to directly inhibit STAT3 activity in vivo
Snyder et al., J Biol Chem 2010 : Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells ... In this report, we demonstrate that Stat3 binds directly to the promoters and regulates the expression of three genes that are essential for cardiac differentiation : Tbx5, Nkx2.5, and GATA4 ... We further demonstrate that Tbx5, Nkx2.5, and GATA4 expression is dependent on Stat3 in response to ligand treatment and during ligand independent differentiation of P19CL6 cells into cardiomyocytes