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CEACAM5 — IL6

Text-mined interactions from Literome

Belluco et al., Ann Surg Oncol 2000 (Colonic Neoplasms...) : Experimental data suggest that carcinoembryonic antigen (CEA) induces the systemic production of IL-6 and that IL-6 may stimulate tumor cell growth at metastatic sites
Filella et al., Tumour Biol 2001 : In contrast, CEA significantly increased the production of IL-6 ( p < 0.001 ) and TNF-alpha ( p = 0.002 ), while PSA significantly decreased IL-1beta ( p < 0.001 ), IL-6 ( p = 0.031 ) and TNF-alpha ( p < 0.0001 ) production
Dukic-Stefanovic et al., J Neurochem 2003 : Chicken egg albumin-AGE (CEA-AGE) , used as model AGE, induces nitric oxide ( NO ), TNF-alpha and IL-6 production
Ullmann et al., J Immunother (1991) 1992 (Colorectal Neoplasms) : Interleukin-6 increases carcinoembryonic antigen and histocompatibility leukocyte antigen expression on the surface of human colorectal carcinoma cells ... Thus, IL-6 can act directly on human colon carcinoma cells and selectively increase the expression of CEA and HLA class I antigens, which may provide some insight into the mechanisms involved in the ability of IL-6 to suppress in vivo tumor growth
Jessup et al., Int J Cancer 2004 (Colorectal Neoplasms...) : Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells ... Carcinoembryonic antigen (CEA) both facilitates the survival of experimental metastasis to nude mouse liver by weakly metastatic human colorectal carcinomas ( CRCs ) and induces the release of the proinflammatory cytokine IL-6
Jessup et al., Clin Exp Metastasis 2004 (Colorectal Neoplasms...) : Since CEA induces release of IL-6 and IL-10, we hypothesized that CEA inhibits the I/R injury through a Kupffer cell mediated cytokine dependent pathway
Dansky-Ullmann et al., Cytokine 1995 (Colonic Neoplasms...) : Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells : role for endogenous IFN-beta ... When administered as single agents, both interferon gamma (IFN-gamma) and interleukin 6 (IL-6) significantly increase carcinoembryonic antigen (CEA) and HLA class I antigen expression on the surface of human colorectal tumour cells
Edmiston et al., Cancer Res 1997 : The CEA induction of IL-6 was a specific response, because the peptide PELPK ( the pentapeptide on CEA that is the ligand for the CEA receptor on Kupffer cells ) conjugated to albumin induced 30 % of the maximal CEA response for IL-6, whereas the specificity control PELGK conjugated albumin did not