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CSF2 — IL6
Text-mined interactions from Literome
Hines et al., Vet Microbiol 1999
:
MIF-A3 does induce secretion of
IL-6 , but does not
induce secretion of TNFalpha, IL-1beta, and
GM-CSF
Yoshida et al., Int Immunol 1999
(Arthritis, Rheumatoid) :
IL-6 and IL-8 induction but not
GM-CSF induction was inhibited in most of the RSF after pretreatment with AuTG
Clark et al., Neurol Res 1999
(Brain Ischemia...) :
These findings confirm that
IL-6 values
increase following CNS ischemia with peak serum and
CSF levels occurring before brain values
Charyulu et al., Int J Oncol 2000
(Mammary Neoplasms, Experimental) :
Rather,
GM-CSF activates
IL-6 production independently of TNF-alpha as demonstrated by neutralization studies using anti-TNF-alpha antibodies
Albanesi et al., J Invest Dermatol 2000
(Dermatitis, Allergic Contact...) :
In addition,
interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage
colony stimulating factor , and interleukin-6, with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Lee et al., Arch Pharm Res 2000
:
High level of macrophage-colony stimulating factor ( M-CSF ) and
interleukin (IL)-6 was
detected in the TFGD-culture supernatant, whereas
granulocyte/macrophage-colony stimulating factor ( GM-CSF ), IL-3, IL-4, IL-5, IL-13, or interferon (IFN)-gamma was undetectable
Kamthong et al., Biochem J 2000
:
cAMP attenuates
interleukin-1 stimulated macrophage
colony stimulating factor ( M-CSF ) expression
Kim et al., J Immunol 2000
:
Thus, HRV-16
induces epithelial expression of IL-8 and
IL-6 by an NF-kappaB independent pathway, whereas induction of
GM-CSF is at least partially dependent upon NF-kappaB activation
Kremlev et al., Nat Immun 1998
(Inflammation) :
We also showed that regardless of the presence or absence of CSF-1 or FN,
IL-6 inhibits
GM-CSF and TNF-alpha gene expression in an autocrine manner
Kamthong et al., Biochem J 2001
:
Inhibitor of nuclear factor-kappaB induction by cAMP antagonizes
interleukin-1 induced human
macrophage-colony-stimulating-factor expression
Ji et al., Acta Pharmacol Sin 2000
:
The
rhM-CSF promoted TNF-alpha,
IL-6 , and IL-8 inductions of monocytes and increased the percentages of CD11b, CD16, HLA I, and HLA II molecule expression on monocytes
Greiber et al., J Am Soc Nephrol 2002
:
GM-CSF release by podocytes was also
stimulated by lipopolysaccharide (LPS),
interleukin-1 (IL-1), and phorbolester ( PMA )
Laurenzi et al., Neurochem Res 2001
:
Granulocyte/macrophage
colony stimulating factor increased the number of process bearing cells, of acetylated LDL binding and of
IL-6 secretion induced by LPS
Yamada et al., J Appl Physiol 2002
:
Plasma granulocyte
colony stimulating factor ( G-CSF ) increased at Post ( P < 0.05 ), and
interleukin-6 (IL-6) increased at Post 1 h ( P < 0.05 )
Hamilton et al., Blood 1992
:
II. Similarities and differences in the control of
interleukin-1 induction of granulocyte-macrophage
CSF and granulocyte-CSF production
Wu et al., Cytokine 2004
(Carcinoma...) :
rhGM-CSF enhanced the production of
IL-6 and VEGF, but had no effect on the antiangiogenic agents endostatin and angiostatin
Oktem et al., Eur J Gynaecol Oncol 2004
(Carcinoma...) :
The
effect of recombinant
GM-CSF on
IL-6 and TNF-alpha levels in epithelial ovarian cancer patients who received paclitaxel and cisplatinum : preliminary results
Dehghani et al., Exp Neurol 2004
(Gliosis) :
In contrast, clodronate significantly reduced the microglial
IL-6-release induced by
M-CSF , indicating different intracellular pathways
Jacobs et al., Skin Pharmacol Physiol 2004
(Warts) :
Analysis of imiquimod treated warts demonstrated that imiquimod enhanced
IL-6 expression and
induced IL-8,
GM-CSF , MRP-8 and MRP-14
Kaminska et al., Tumour Biol 2005
(Colorectal Neoplasms) :
The levels of circulating interleukin (IL)-6, IL-8, macrophage
colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly
increased with the clinical stage of CRC, and the levels of
IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ), soluble interleukin 2 receptor alpha and TNFalpha with tumor grade, while IL-6, IL-8, M-CSF, IL-1ra and sTNF RI levels significantly rose with bowel wall invasion
Matsuzaki et al., Cancer Sci 2006
:
We have demonstrated previously that the Th1-cytokine conditioned bone marrow derived dendritic cell ( BMDC ) subset BMDC1 ( generated in the presence of granulocyte-macrophage colony stimulating factor [GM-CSF ]
+ interleukin [ IL]-3 + interferon [ IFN]-gamma+ IL-12 )
induces a much stronger type 1 immune response than BMDC0 (
GM-CSF + IL-3 )
Lu et al., Invest Ophthalmol Vis Sci 2006
:
Lipopolysaccharide (LPS)
induced the release of the proinflammatory cytokine
IL-6 and that of the chemokines G-CSF, MCP-1, MIP-1beta, and IL-8 as well as surface expression of ICAM-1 by corneal fibroblasts, whereas IL-1beta, TNF-alpha, and
GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS
Leizer et al., Blood 1990
:
Cytokine regulation of colony stimulating factor production in cultured human synovial fibroblasts : I.
Induction of
GM-CSF and G-CSF production by
interleukin-1 and tumor necrosis factor
Zaheer et al., J Neurochem 2007
(Encephalitis...) :
The
GM-CSF dependent expression and secretion of inflammatory cytokine/chemokine, TNF-alpha, IL-1beta,
IL-6 , and IP-10, is cytotoxic to oligodendrocytes, the myelin forming cells in the central nervous system, and as well as neurons
Laing et al., J Appl Physiol 2008
:
EX-C blunted the circulating norepinephrine, cortisol,
granulocyte-colony stimulating factor , and
IL-6 response ( P < 0.01 ) but not the plasma epinephrine and serum growth hormone response
Kim et al., J Korean Med Sci 2008
(Prostatic Neoplasms) :
The aim of this study was to evaluate the
effects of
GM-CSF on the expression of
IL-6 in prostate cancer-3 (PC-3) cells
Sonderegger et al., J Exp Med 2008
(Autoimmune Diseases...) :
We found that innate
GM-CSF was
critical for
IL-6 and IL-23 responses by dendritic cells and generation of pathological Th17 cells in vivo
Yang et al., BMC cell biology 2009
:
At 10 ng/ml,
GM-CSF significantly
enhanced R-848 induced
IL-6 release from P815 cells
Han et al., Int J Hematol 1991
(Hematologic Diseases) :
Critical analysis of these data indicates that : ( i ) megakaryocytopoiesis is a complex, multiple-stage cellular and biologic process ; ( ii ) the survival, proliferation and differentiation of progenitor cells into immature megakaryocytes are regulated mainly by interleukin-3, granulocyte-macrophage colony stimulating factor and an as yet uncharacterized megakaryocyte
colony stimulating factor , and the maturation of immature megakaryocytes to produce platelets is
regulated primarily by
interleukin-6 and thrombopoietin; (iii) optimal megakaryocyte development needs adequate interactions of several growth factors with target cell population and hematopoietic microenvironment ; ( iv ) megakaryocytopoietic inhibition is controlled essentially by megakaryocyte-platelet products such as transforming growth factor-beta, and platelet factor 4 and its related proteins ; interferon-alpha and -gamma also are able to play an inhibitory role ; and ( v ) expansion or decrease of either normal or neoplastic megakaryocyte progenitor cells, change of platelet mass and abnormalities of growth factor levels in hematopoietic tissue might result in an abnormal megakaryocytopoiesis
Essner et al., J Clin Lab Immunol 1990
:
Differential
effects of granulocyte-macrophage
colony stimulating factor and macrophage colony stimulating factor on tumor necrosis factor and
interleukin-1 production in human monocytes
Hashimoto et al., J Exp Med 2010
(Arthritis...) :
GM-CSF secreted by activated T cells indeed
enhanced in vitro
IL-6 production by C5a stimulated macrophages
Nozaki et al., J Invest Dermatol 1991
:
Augmentation of granulocyte/macrophage
colony stimulating factor expression by ultraviolet irradiation is
mediated by
interleukin 1 in Pam 212 keratinocytes
Ito et al., Arthritis Res Ther 2011
(Arthritis, Rheumatoid...) :
Exogenous addition of IL-17 dramatically
enhanced the spontaneous production of
IL-6 and prostaglandin E2 ( PGE2 ) by the ST-derived inflammatory cells, while it had no effect on the production of tumor necrosis factor (TNF)-a and macrophage
colony stimulating factor ( M-CSF )
Wang et al., Int J Oncol 1995
:
We report that all-trans retinoic acid ( tRA ) synergizes with LPS to
enhance the production of granulocyte
colony stimulating factor ( G-CSF ) in PMA treated cells, whereas the production of granulocyte-macrophage CSF,
interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA
Wetzler et al., Cancer Res 1990
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
However, granulocyte
colony stimulating factor expression could be induced by recombinant human IL-1 beta ; while
IL-6 could be
induced by both IL-1 beta and tumor necrosis factor-alpha
Rodriguez-Cimadevilla et al., Blood 1990
(Leukemia, Myeloid, Acute) :
Coordinate secretion of interleukin-1 beta and granulocyte-macrophage
colony stimulating factor by the blast cells of acute myeloblastic leukemia :
role of
interleukin-1 as an endogenous inducer
Szardien et al., Eur Heart J 2012
(Aortic Valve Stenosis...) :
Regression of cardiac hypertrophy by granulocyte
colony stimulating factor stimulated
interleukin-1ß synthesis
Zhang et al., Blood 1990
(Multiple Myeloma) :
rGM-CSF did not reproducibly
increase the endogenous
IL-6 production in short-term cultures of bone marrow cells of MM patients ...
rGM-CSF did not
induce any
IL-6 production in XG-1 cells, nor was it able to sustain their growth alone ... Although no detectable GM-CSF levels were found in the peripheral or bone marrow blood of MM patients, it is possible that
GM-CSF , produced locally by the tumoral environment,
enhances the
IL-6 responsiveness of myeloma cells in vivo in a way similar to that reported here in vitro
Sjölinder et al., Infect Immun 2012
:
NhhA
induced transcription of
IL-6 and G-CSF mRNA via TLR4 dependent pathways, whereas
GM-CSF transcription was induced via TLR4 independent pathways
Suzuki et al., J Perinatol 2013
:
Serum levels of
IL-6 and IL-8 had been already elevated in his cord blood, and serum levels of granulocyte-macrophage
colony stimulating factor and IL-8 were significantly
increased on the second day of life
Bradbury et al., Leukemia 1990
(Leukemia, Myeloid, Acute) :
Endogenous
interleukin-1 can
regulate the autonomous growth of the blast cells of acute myeloblastic leukemia by inducing autocrine secretion of
GM-CSF
Bot et al., Blood 1989
:
Human multilineage
colony stimulating factor ( multi-CSF )
/interleukin-3 (IL-3)
induces colony formation from CFU-GEMM, BFU-E, and CFU-Eo when applied to in vitro cultures of highly enriched hematopoietic progenitor cells
Schaafsma et al., Blood 1989
:
Because IL-6 is coinduced with colony stimulating factors ( CSFs ) by various cell types in response to stimulation with IL-1, we investigated whether
IL-6 is
involved in the IL-1 induced production of
CSF by human bone marrow ( BM ) cells in long-term culture or human fibroblasts ... We showed that
IL-6 does not
induce CSF production by these cells ... We conclude that
IL-6 , either alone or in combination with IL-1, does not
induce CSF production by human BM stromal cells or fibroblasts
Morrissey et al., Int Arch Allergy Appl Immunol 1989
(Chagas Disease) :
Thus, we have found that exogenous
GM-CSF augments the primary plaque forming response to sheep red blood cells and that this effect is
due to upregulation of Ia antigen expression and
interleukin 1 production by the macrophages
Motoyoshi et al., Exp Hematol 1989
:
On the other hand,
CSF-HU did not
stimulate monocyte production of
interleukin-1 and interferon
Taga et al., J Exp Med 1987
(Astrocytoma...) :
Binding of
125I-BSF-2 to CESS was competitively
inhibited by unlabeled BSF-2 but not by IL-1, IL-2, IFN-beta, IFN-gamma, and
G-CSF , indicating the presence of the receptors specific for BSF-2
Kleinerman et al., Cancer Res 1988
(Neoplasms) :
rGM-CSF in vitro also did not
stimulate the tumoricidal function of normal monocytes or the secretion of
interleukin-1 or tumor necrosis factor
Murata et al., Neurol Med Chir (Tokyo) 1993
(Glioblastoma) :
Exogenous
GM-CSF stimulation
had no effect on production of prostaglandin E2,
interleukin-6 , or interleukin-8 by glioma cells
Rameshwar et al., J Immunol 1994
:
The induction of IL-3 and
GM-CSF is partially
mediated by IL-1 and
IL-6 , which are also produced by bone marrow mononuclear cells
Alderson et al., J Exp Med 1993
:
CD40 ligand transfected cells provided a potent costimulus for monocyte TNF-alpha and
IL-6 production in the
presence of
GM-CSF , IL-3, or IFN-gamma, and enhanced IL-8 production stimulated by GM-CSF or IL-3
Kawasaki et al., J Antibiot (Tokyo) 1995
:
Concerning positive hematopoietic regulators, MeDSG had a slight enhancing effect on the release of granulocyte-macrophage
colony stimulating factor and a slight inhibitory
effect on the release of
interleukin-6 and granulocyte-colony stimulating factor from PBMC stimulated with mitogens
Yokoshima et al., Nihon Jibiinkoka Gakkai Kaiho 1995
(Nose Neoplasms...) :
Immunohistochemical study revealed the distribution of cytokines :
GM-CSF was
detected near the basement membrane of the tumor site, while
IL-6 and IL-8 were detected in the superficial layer of nasal inverted papilloma
Pullyblank et al., Br J Cancer 1994
(Adenocarcinoma...) :
Similarly,
interleukin 2 receptor (IL-2R) expression ( percentage of positive cells ) was augmented in the
presence of m17-1A ( 15 +/- 3 ), c17-1A ( 14 +/- 3 ) and
cSF25 ( 25 +/- 3 ) when compared with no antibody ( 9 +/- 2 )
Hladik et al., J Immunol 1994
:
A single application of 30,000 U nIL-2
induced selective and long lasting expression of IL-2, IFN-gamma, and
GM-CSF genes, which was not accompanied by accumulation of TNF-alpha and
IL-6 mRNAs
Gautam et al., Oncol Res 1993
(Astrocytoma) :
Interferon gamma (IFN gamma), transforming growth factor beta 1 ( TGF-beta 1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ) and
granulocyte-colony stimulating factor ( G-CSF ) did not
induce IL6 mRNA production ; however,
IL6 mRNA expression and protein production was strongly induced by IL1 alpha and to a lesser extent by IFN alpha
Bender et al., J Immunol 1993
:
In virus infected monocytes,
GM-CSF induced a more rapid IFN-alpha release and
potentiated production of TNF-alpha, IL-1 beta, and
IL-6
Rizzo et al., Exp Hematol 1994
:
Regulation of
interleukin-1 and tumor necrosis factor-alpha
induced granulocyte-macrophage
colony stimulating factor gene expression : potential involvement of arachidonic acid metabolism
Akahane et al., Exp Hematol 1993
:
In the present study, we show that
GM-CSF production in murine aorta derived vascular endothelial cells is
regulated by two cytokines
: interleukin-1 (IL-1), which induces the production of GM-CSF, and interferon gamma (IFN-gamma), which downregulates this production
Mori et al., Rinsho Ketsueki 1993
(Eosinophilia...) :
The activity of granulocyte-macrophage
colony stimulating factor ( GM-CSF ) was
detected in the supernatant of the cultured ATL cells, although interleukin-3,
interleukin-5 , and GM-CSF activities were not detected in her serum
Bataille et al., La Revue du praticien 1993
(Multiple Myeloma) :
GM-CSF , IL-3 and G-CSF
stimulate the
IL-6 responsiveness of myeloma cells without affecting the endogenous IL-6 production
Takamatsu et al., J Immunol 1996
:
GM-CSF and IL-3 also
caused a marked accumulation of both histidine decarboxylase and
IL-6 mRNAs in the cells
Haynesworth et al., J Cell Physiol 1996
:
In contrast, IL-1 alpha increased the expression of G-CSF, M-CSF, LIF,
IL-6 and IL-11 and
induced the expression of
GM-CSF
Li et al., Exp Hematol 1996
(Leukemia, Monocytic, Acute) :
Regulation of granulocyte-macrophage
colony stimulating factor ( GM-CSF ) receptors in a GM-CSF dependent human myeloid leukemia cell line ( AML-193 ) by
interleukin-6
van Pelt et al., Blood 1996
:
GM-CSF induced the release of interleukin-8 (IL-8), but not of
IL-6 or tumor necrosis factor alpha
Saito et al., J Immunol 1996
:
PGE2 enhanced the SF- and IL-6 dependent development of mast cells from CBMC probably by blocking granulocyte-macrophage CSF (GM-CSF) secretion from accessory cells, because 1 ) PGE2, or anti-GM-CSF enhanced the mast cell development induced by SF and IL-6 from CBMC, but not from CD34+ cells ; 2 ) GM-CSF
inhibited the enhancing effect of
IL-6 on the mast cell development from CD34+ cells ; and 3 ) PGE2 inhibited
GM-CSF secretion from CBMC
Kruger et al., Immunology 1996
:
The cytokines interleukin-1 beta (IL-1 beta) and IL-2 strongly
enhanced GM-CSF production, while IL-4,
IL-6 , GM-CSF, interferon-gamma (IFN-gamma) and tumour necrosis factor (TNF) had no effect
Suzumura et al., Brain Res 1996
:
Selective
induction of
interleukin-6 in mouse microglia by granulocyte-macrophage
colony stimulating factor ...
GM-CSF induced
interleukin-6 (IL-6) production by microglia, but not by astrocytes, in a dose dependent manner as assessed by bioassay and the detection of IL-6 mRNA by reverse transcriptase-polymerase chain reaction ( RT-PCR ) analysis ... The
induction of
IL-6 by
GM-CSF in microglia was completely inhibited by antibodies to GM-CSF
Le Meur et al., Kidney Int 1996
(Uremia) :
Since macrophage
colony stimulating factor ( M-CSF ) is
essential for the activation of several functions of monocytes and macrophages and their production of cytokines such as
interleukin-1 , interleukin-6, and tumor necrosis factor alpha, we investigated its involvement in patients with CRF
Bruserud et al., Acta Haematol 1996
(Leukemia, Myeloid, Acute) :
IL1 beta, granulocyte-macrophage colony stimulating factor, macrophage
colony stimulating factor and stem cell factor
increased IL6 secretion, whereas IL4 caused decreased IL6 secretion together with increased release of IL1 receptor antagonist
Lemaire et al., J Immunol 1996
:
In contrast,
IL-6 mRNA expression was
increased by
GM-CSF but not M-CSF ... Kinetic analysis indicated that
GM-CSF stimulated
IL-6 expression early ( 1.5 h ), with maximal effect observed at 24 h and up to 5 days thereafter
Foli et al., AIDS Res Hum Retroviruses 1997
(HIV Infections) :
However, granulocyte-macrophage
colony stimulating factor ( GM-CSF ), a cytokine that enhances HIV replication in M/Ms and is frequently used to propagate monocytotropic strains of HIV, can
induce the relatively long-term production of
IL-6 ( up to 47 U/ml ) and TNF-alpha ( up to 47 pg/ml ) by M/Ms, even in the absence of HIV
Kamdar et al., Exp Cell Res 1997
:
Recent data have indicated that resident mouse peritoneal macrophages ( PMo ) transcribed the
interleukin 6 (Il6) and granulocyte-macrophage colony stimulating factor ( Csfgm ) genes in
response to stimulation with the monocyte-macrophage
colony stimulating factor ( CSF-1 ) but only Il6 mRNA was translated into secreted protein
Asakura et al., Immunopharmacology 1997
:
However,
M-CSF-injection had lesser effects on LPS induced
IL-6 production from liver, alveolar and peritoneal macrophages
Rougier et al., Cytokine 1998
:
IL-1 alpha, IL-1 beta, and IL-3, tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage
colony stimulating factor ( GM-CSF ) ( at 10 ng/ml )
stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Murphy et al., J Biol Chem 1998
(Alzheimer Disease) :
Macrophage
colony stimulating factor augments beta-amyloid
induced interleukin-1,
interleukin-6 , and nitric oxide production by microglial cells ... We showed that macrophage
colony stimulating factor , a microglial activator found at increased levels in the central nervous system in AD, dramatically
augments beta-amyloid peptide ( betaAP ) -induced microglial production of
interleukin-1 , interleukin-6, and nitric oxide
Weimann et al., J Perinat Med 1998
(Chorioamnionitis...) :
G-CSF , GM-CSF and IL-6 levels in cord blood :
diminished increase of G-CSF and
IL-6 in preterms with perinatal infection compared to term neonates
Menetrier-Caux et al., Blood 1998
(Carcinoma, Renal Cell) :
Interleukin-6 (IL-6) and macrophage
colony stimulating factor ( M-CSF ) were found to be responsible for this phenomenon : antibodies against IL-6 and M-CSF abrogated the inhibitory effects of RCC CM ; and recombinant
IL-6 and/or M-CSF
inhibited the differentiation of DC similarly to RCC CM
Evans et al., J Leukoc Biol 1998
:
CSF-1 regulation of
Il6 gene expression by murine macrophages : a pivotal
role for
GM-CSF ...
GM-CSF induces
Il6 gene expression and synergizes with CSF-1 to induce the release of large amounts of IL-6 ... Exogenous recombinant
GM-CSF restored the
IL-6 response of GM-CSF null PMphi to a great extent but not completely