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CDKN1A — NOX5
Text-mined interactions from Literome
Katsume et al., Arterioscler Thromb Vasc Biol 2011
(Aortic Diseases...) :
Lysophosphatidylcholine activated PYK2 induced
NADPH oxidase mediated ROS generation and ROS mediated synthesis of tumor necrosis factor-a (TNFa), vascular cell adhesion molecule-1 ( VCAM-1 ), monocyte chemotactic protein-1 (MCP-1), and
p21Cip1/Ets-1
Bromberg et al., J Biol Chem 1994
:
The GDP bound form of the small G protein Rac1
p21 is a potent
activator of the superoxide forming
NADPH oxidase of macrophages ... The GDP bound form of Rac1
p21 complexed to Rho GDI functioned as a potent
activator of
NADPH oxidase in a cell-free system that contained no free GTP or ATP ... We propose that the GDP bound form of Rac1
p21 might be the physiological
activator of
NADPH oxidase in macrophages, following its dissociation from Rho GDI, and that nucleotide exchange or conversion to GTP is not necessarily involved
Sawai et al., Biochem Biophys Res Commun 1993
(Leukemia, Promyelocytic, Acute) :
Combination of arachidonic acid and guanosine 5'-O- ( 3-thiotriphosphate ) induce translocation of rac
p21s to membrane and
activation of
NADPH oxidase in a cell-free system