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LPA — SERPINE1

Text-mined interactions from Literome

Ren et al., Am J Physiol Endocrinol Metab 2000 (Translocation, Genetic) : Treatments with 60 nM 379196, a PKC-beta-specific inhibitor, effectively prevented PAI-1 production induced by LDL, Lp(a) , or their oxidized forms in HUVEC and human coronary artery EC
Zhang et al., Atherosclerosis 2000 (Cardiovascular Diseases...) : Treatment with aminoguanidine, an inhibitor for the formation of advanced glycation end products ( AGEs ), during glycation normalized the generation of PAI-1 and t-PA induced by glycated Lp(a) ... Butylated hydroxytoluene, a potent antioxidant, inhibited native and glycated Lp(a) induced changes in PAI-1 and t-PA generation in EC ... The results indicate that glycation amplifies Lp(a) induced changes in the generation of PAI-1 and t-PA from venous and arterial EC
Buechler et al., Blood 2001 (Coronary Disease...) : Purified Lp(a) induced PAI-2 mRNA and protein and reduced PAI-1 expression in monocytes isolated from various controls
Beaudeux et al., Life Sci 2001 : The results showed that O2*-/HO* free radical oxidized LDL and Lp(a) led to a dramatic decrease of PAI-1 release but did not affect tPA release, whereas copper oxidation of lipoproteins resulted in an increase in PAI-1 release and a decrease in tPA release ... Thus, the discordant effects of O2*-/HO* oxidized and copper oxidized LDL and Lp(a) on the endothelial releases of PAI-1 and tPA appeared to be due to qualitatively and/or quantitatively different formation of oxidized components by the two oxidation processes
Zhu et al., Hunan Yi Ke Da Xue Xue Bao 1999 (Kidney Failure, Chronic) : Plasma Lp (a) concentration and activation of tissue-type plasminogen activator ( t-PA ) and plasminogen activator inhibitor-1(PAI-1) were determined in 50 patients with chronic renal failure (CRF) and in 50 healthy subjects
Shen et al., Mol Cell Biochem 2003 (Cardiovascular Diseases...) : Activation of protein kinase C is required for oxidized LDL or Lp(a) induced PAI-1 production in EC
Edelberg et al., J Biol Chem 1991 : In addition, these experiments indicate that Lp(a) may regulate fibrinolysis by competing with PAI-1 and plasminogen for fibrinogen- and heparin bound t-PA
Vucković et al., Srp Arh Celok Lek 2010 (Brain Ischemia...) : However, in the cases, but not in the controls, multivariate analysis of associations between fibrinolytic parameters and Lp(a) showed the highest correlation between t-PA and PAI-1, and the latent effect of Lp(a) on t-PA and PAI-1
Ren et al., Atherosclerosis 1997 : The present paper examined the effects of oxidized Lp(a) on the production of PAI-1 in cultured human umbilical vein endothelial cells ( HUVEC ) ... The release of PAI-1 induced by Lp(a) was enhanced by oxidative modification with copper ion ... The results of the present paper demonstrate that oxidative modification enhances Lp(a) induced PAI-1 production in vascular endothelial cells at RNA transcription level, which suggests that oxidization potentially amplifies the anti-fibrinolytic and thrombotic effect of Lp(a)
Li et al., Arterioscler Thromb Vasc Biol 1997 (Arteriosclerosis...) : Genotype-specific transcriptional regulation of PAI-1 expression by hypertriglyceridemic VLDL and Lp(a) in cultured human endothelial cells ... These combined results demonstrate the genotype-specific regulation of PAI-1 expression by HTG-VLDL and Lp(a) and further indicate that these risk factor associated components regulate PAI-1 gene expression at the transcriptional level in cultured HUVECs