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IRS1 — SH2B3

Text-mined interactions from Literome

Duan et al., Mol Cell Biol 2004 (Glucose Intolerance...) : Moreover, SH2-B directly enhanced autophosphorylation of insulin receptor and tyrosine phosphorylation of IRS1 and IRS2 in an SH2 domain dependent manner in cultured cells
Duan et al., J Biol Chem 2004 : Consequently, SH2-B dramatically enhanced leptin stimulated tyrosine phosphorylation of IRS1 and IRS2 in HEK293 cells stably expressing LRb, thus promoting association of IRS1 and IRS2 with the p85 regulatory subunit of PI 3-kinase and phosphorylation and activation of Akt ... Similarly, SH2-B promoted growth hormone stimulated tyrosine phosphorylation of IRS1 in both HEK293 and MEF cells