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EPHB2 — PC

Text-mined interactions from Literome

Machala et al., Toxicological sciences : an official journal of the Society of Toxicology 2003 : Using Western blot analysis with phospho-specific antibodies, it was found that PCB 153, and not PCB 126, activated mitogen activated protein kinases ERK1/2 ; however in contrast to TPA and EGF, this activation was observed at the time points subsequent to GJIC inhibition ... Moreover, blocking of ERK1/2 activation did not prevent the GJIC inhibition induced by PCB 153
Umannová et al., Toxicology 2008 : Although PCB 153 induced both ERK1/2 and p38 activation, the specific p38 kinase inhibitor, SB203580, had no effect on AA release
Simecková et al., Toxicological sciences : an official journal of the Society of Toxicology 2009 : PCB 153 contributed to extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) -dependent accumulation of hyperphosphorylated Cx43-P3 form, thus indicating that ERK1/2 activation by PCB 153 might contribute to its effects on Cx43 internalization or degradation
Fan et al., Toxicol Appl Pharmacol 2010 : PCB 47 also increased phospho-ERK1/2 like its structural analog PBDE 47, but to a lesser extent, suggesting that these chemicals affect similar pathways