Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Eşrefoğlu et al., Pancreatology 2006 (Pancreatitis) : Ascorbic acid + NAC decreased MDA levels but increased CAT , SOD, GPx activities and GSH levels ( p < 0.005 )
Popovic et al., Eur J Drug Metab Pharmacokinet 2007 : NAC , Se, DVP, MKH and DVPMKH caused a reduction in CAT activity, while DVPSOD and DVPSe caused an increase of the latter
Poncin et al., J Endocrinol 2009 : Among antioxidant systems, peroxiredoxin ( PRDX ) five expression was reduced by NAC , whereas peroxiredoxin three increased and catalase remained unchanged
Cheung et al., J Cell Biochem 2010 (Colonic Neoplasms) : The SAA cytotoxicity was blocked by co-incubation with catalase, whereas the SBA cytotoxicity and its subsequent growth arrest were abolished by N-acetyl-L-cysteine (NAC) , but was not affected by PI3K phosphorylation inhibitor LY294002, or catalase , suggesting two separated oxidative stress pathways were mediated by these two ascorbates