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IL1A — IL1R2

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: IL1A/IL1B → IL1R1/IL1R2 (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: IL1A → Complex of IL1R2-IL1RAP (protein-protein, activation)
• NCI Pathway Database IL1-mediated signaling events: IL1R2 (IL1R2) → IL1 alpha (IL1A) (modification, collaborate) Symons et al., Proc Natl Acad Sci U S A 1995*
• NCI Pathway Database IL1-mediated signaling events: IL1R2 (IL1R2) → IL1 alpha/IL1R2 complex (IL1A-IL1R2) (modification, collaborate)
  Symons et al., Proc Natl Acad Sci U S A 1995*
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha (IL1A) → IL1 alpha/IL1R2 complex (IL1A-IL1R2) (modification, collaborate)
  Symons et al., Proc Natl Acad Sci U S A 1995*
• Reactome Reaction: IL1A → IL1R2 (direct_complex) Colotta et al., Science 1993*
• Reactome Reaction: IL1A → IL1R2 (reaction) Colotta et al., Science 1993*
• WikiPathways MAPK Signaling Pathway: IL1B/IL1A → IL1R2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: IL1R2 — IL1A (in vitro) Symons et al., Proc Natl Acad Sci U S A 1995*
• IRef Innatedb Interaction: IL1R2 — IL1A (unknown, -) McMahan et al., EMBO J 1991*
• IRef Innatedb Interaction: IL1R2 — IL1A (unknown, -) Zheng et al., Immunity 2013*
• IRef Ophid Interaction: IL1R2 — IL1A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: IL1R2 — IL1A (aggregation, confirmational text mining) Symons et al., Proc Natl Acad Sci U S A 1995*

Text-mined interactions from Literome

Bourdiec et al., Biol Reprod 2012 : Overexpression of IL1R2 using cell transfection inhibited IL1 and hCG/IL1B mediated MCP1 secretion
Colotta et al., Science 1993 : These results, together with the effect of antibodies to IL-1R on IL-1 induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1