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MAPK1 — RASA1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nori et al., Mol Cell Biol 1992
:
Reduction of
GAP expression to near normal levels
restored the ability of the cells to activate
p42mapk in response to TPA
Van Slyke et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Dok-R 's ability to attenuate EGF-driven
MAPK activation is
independent of its ability to recruit
rasGAP , a known attenuator of MAPK activity, suggesting an alternate Dok-R mediated pathway
Zhao et al., Mol Cell Biol 2006
:
On the other hand, Dok-1 negatively
regulates PDGF induced
MAPK activation by acting on
Ras-GAP and at least one other Dok-1 interacting protein
Szczur et al., Blood 2006
(MAP Kinase Signaling System) :
We further suggest that CDC42GAP mediated extracellular signal regulated kinase ( ERK ) activity regulates motility associated with podosome-like structures at the cell leading edge, while
CDC42GAP induced p38 (
MAPK ) phosphorylation regulates directed migration by antagonizing filopodia assembly
Vilá de Muga et al., Oncogene 2009
:
In ER-negative MDA-MB-436 cells, overexpression of p120GAP, but not CAPRI or a
p120GAP mutant lacking the AnxA6 binding domain
inhibits Ras/MAPK activity
Yao et al., Oncogene 1995
:
GAP overexpression also
inhibited stimulation of
mitogen activated protein ( MAP ) kinase and induction of immediate-early genes in response to NGF