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SOCS1 — TLR4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TLR4 → SOCS1 (decreases, SOCS1 Activity) Kinjyo et al., Immunity 2002*
  Evidence: We show here that the suppressor of cytokine-signaling-1 (SOCS1/JAB) is rapidly induced by LPS and negatively regulates LPS signaling. Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity.

Text-mined interactions from Literome

Kinjyo et al., Immunity 2002 : Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity
Mun et al., Infect Immun 2005 : On the other hand, signaling of TgHSP70 induced tolerance was mediated by TLR4 , and the expression of SOCS-1 suppressed the TLR2 signaling pathway
Bartz et al., Blood 2006 : The results indicate that TLR stimulation during the period of DC generation interferes with and deviates DC differentiation and that these effects are mediated particularly by SOCS-1
Okumura et al., J Virol 2010 (Inflammation) : Here we report that host Toll-like receptor 4 (TLR4) is a sensor for Ebola virus glycoprotein ( GP ) on virus-like particles ( VLPs ) and that resultant TLR4 signaling pathways lead to the production of proinflammatory cytokines and suppressor of cytokine signaling 1 ( SOCS1 ) in a human monocytic cell line and in HEK293-TLR4/MD2 cells stably expressing the TLR4/MD2 complex
Tajiri et al., J Immunol 2012 (Autoimmune Diseases...) : Suppressor of cytokine signaling (SOCS) 1 plays a key role in the negative regulation of both TLR- and cytokine receptor mediated signaling, which is involved in innate immunity and subsequent adaptive immunity