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GDNF — MAPK9
Text-mined interactions from Literome
Nicole et al., J Neurosci 2001
(Brain Ischemia...) :
Together, these results describe a novel mechanism by which the activation of
MAPK induced by
GDNF modulates NMDA receptor activity, a mechanism that could be responsible for the neuroprotective effect of GDNF in acute brain injury
Hisaoka et al., J Neurochem 2001
(Glioblastoma) :
These results suggested that amitriptyline induced
GDNF synthesis and release occurred at the transcriptional level, and may be
regulated by
MEK/MAPK signalling
Wiklund et al., J Neurosci Res 2002
(MAP Kinase Signaling System) :
Other findings indicate that
GDNF exerts its growth effects by activation of MAPK and that expression of the conditioning effect in vitro in preaxotomized preparations also
requires activation of
MAPK
Steinkamp et al., Gastroenterology 2003
:
GDNF induced activation of Akt ( protein kinase B [PKB ] ) and
mitogen activated protein kinase ( MAPK ) in the colonic epithelial cell lines HT-29 and SW480 was studied ...
GDNF potently
activated MAPK and Akt ( PKB ) in colonic epithelial cells
Sawai et al., Cancer Res 2005
(Adenocarcinoma...) :
The modifying effect of G691S RET on
GDNF induced invasion and
mitogen activated protein kinase ( MAPK ) signaling was evaluated
Sooranna et al., J Cell Physiol 2007
(MAP Kinase Signaling System) :
All three stimuli increased PGHS-2 and IL-8 mRNA expression in a MAPK dependent manner, but while the
MAPK inhibitors
reduced the IL-1beta induced activation of
activating transcription factor (ATF)-2 , liver activating protein (LAP) and c-jun, the stretch induced increase in LAP was unaffected by MAPK-inhibition and only JNK inhibition appeared to reduce c-jun activation
Koeberle et al., Cell Death Differ 2008
:
However,
GDNF also
required Src and
mitogen activated protein kinase activity to prevent RGC apoptosis
Ledda et al., J Neurosci 2008
:
In particular, we demonstrate that Lrig1 is capable of physically interacting with Ret and that Lrig1/Ret association inhibits GDNF binding, recruitment of Ret to lipid rafts, receptor autophosphorylation, and
mitogen activated protein kinase ( MAPK ) activation in
response to
GDNF ... Downregulation of Lrig1 using small interference RNA knock-down experiments potentiates both neuronal differentiation and
MAPK activation in
response to
GDNF
Battaglia et al., PloS one 2009
:
In pure cultures of striatal neurons, the increase in
GDNF induced by LY379268
required the activation of the
mitogen activated protein kinase and phosphatidylinositol-3-kinase pathways, as shown by the use of specific inhibitors of the two pathways
Chatterjee et al., Hum Genet 2012
(Vesico-Ureteral Reflux) :
A family with duplicated collecting system had a novel mutation, RET-R831Q, which showed markedly decreased
GDNF dependent
MAPK activity