◀ Back to MAPK8
MAP3K3 — MAPK8
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP3K3
(increases, MAP3K3 Activity, MAPK8 Activity)
Evidence: Upon binding of IL-1 to IL-1RI, an IL-1RAcP is recruited to form a high affinity IL-1R1-IL-1RAcP heterodimeric receptor, which initiates the downstream signaling cascade. The trimeric complex rapidly assembles MyD88 and IRAK4 and forms a stable IL-1-induced first signaling module, which subsequently phosphorylates IRAK1 and IRAK2, and recruits TRAF6. Complexes of IRAK1, IRAK2 and TRAF6 dissociate from the initial receptor complex and promote TGF?-activated protein kinase (TAK)1/TAK-binding prote...
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WikiPathways EBV LMP1 signaling:
Complex of MAP3K7-TAB1-MAP3K3-TRAF6
→
MAPK8
(activation)
Text-mined interactions from Literome
Deacon et al., J Biol Chem 1999
:
We have examined the
regulation by
MEKK3 of
MAPK kinase 7 ( MKK7 ) and MKK6, two novel MAPK kinases specific for JNK and p38, respectively
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Wang et al., J Immunol 2011
(MAP Kinase Signaling System) :
Furthermore, the IL-12/IL-18-driven IFN-? production and MAPK activation in Mekk3-deficient T cells was not affected suggesting that
MEKK3 may selectively
mediate the TCR induced
MAPK signals for IFN-? production