Derebecka-Holysz et al., Mol Cell Biochem 2008
:
In conclusion, our results suggest that the inhibitory action of TGF-beta on CYP17 transcription involve at least two mechanisms : SMAD3 dependent inactivation of CYP17 promoter activity and repression of SF-1 expression
Liang et al., Endocrinology 2011
:
RNA interference and chromatin immunoprecipitation studies also demonstrated that Smad3 was required for SF-1 binding to Cyp19a1 type II promoter and activation of Cyp19a1