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CDK2 — WEE1

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDK2 → WEE1 (direct_complex)
• Reactome Reaction: CDK2 → WEE1 (reaction) Gu et al., EMBO J 1992*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: WEE1 — CDK2 (in vitro) Watanabe et al., EMBO J 1995*

Text-mined interactions from Literome

Chen et al., J Biol Chem 2004 (MAP Kinase Signaling System) : This results from the phosphorylation and subsequent inactivation of two inhibitory kinases ( WEE1 and MYT1 ) that tonically suppress CDK2 and CDC2 activity and activation of a phosphatase ( CDC25A ) that increases CDK2 activity
Li et al., Mol Cell Biol 2010 : RXL1 and T239 mutants each mediated greater Cdk phosphorylation and G ( 2 ) /M inhibition than the wild type, suggesting that cyclin A/Cdk complexes inhibit human Wee1 through these sites
Cook et al., J Exp Bot 2013 : Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint : it is high during S-phase but drops as cells traverse G2 and enter mitosis
Wu et al., EMBO J 1997 : In Schizosaccharomyces pombe, the activity of the M-phase inducing Cdc2/Cdc13 cyclin dependent kinase is inhibited by Wee1 and Mik1 tyrosine kinases, and activated by Cdc25 and Pyp3 tyrosine phosphatases