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CYP11A1 — EGF

Text-mined interactions from Literome

Pestell et al., J Biol Chem 1995 : In contrast, EGF induced CYP11A1 transcription through an adjacent but distinct sequence ( -92 to -77 base pairs ) that was shown previously to bind nuclear proteins in DNase I footprinting reactions ... We conclude that EGF stimulates the CYP11A1 promoter through an AP-1 like element and that c-Jun is one of the targets of EGF action
Pestell et al., Mol Endocrinol 1996 (Choriocarcinoma) : Expression of the ovine P-450 side-chain cleavage enzyme gene ( CYP11A1 ) is stimulated by epidermal growth factor (EGF) through a pathway that involves c-Jun in JEG-3 placental cells ... We investigated the intracellular signaling pathways governing EGF induction of the CYP11A1 promoter ... EGF induced CYP11A1 promoter activity was reduced 60 % by the MEK1 inhibitor PD098059 and 50 % by a dominant negative mutant of the ERK-specific regulator MEK1 ... In contrast, dominant negative mutants of the SAPK-specific activator, SEK1, induced a further increase in EGF induced CYP11A1 promoter activity ... Induction of the CYP11A1 promoter by EGF involves a ras/MEK1/AP-1 dependent pathway that is distinct from induction by ras/c-Ets-2