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SETD2 — SOD2

Text-mined interactions from Literome

Kim et al., Pulmonary circulation 2011 : The partial silencing of SOD2 alters redox signaling, activates HIF-1a ) and leads to excessive cell proliferation
Yuan et al., Proc Natl Acad Sci U S A 2013 (Anoxia) : Conversely, in Hif1a ( +/- ) mice, partial HIF-1a deficiency increased levels of HIF-2a and superoxide dismutase 2, leading to a reduced intracellular redox state, blunted oxygen sensing, and impaired carotid body and ventilatory responses to chronic hypoxia, which were corrected by treatment with a HIF-2a inhibitor
Gao et al., Biochem Biophys Res Commun 2013 (Carcinoma, Renal Cell...) : Down-regulation of the mitochondrial enzyme superoxide dismutase 2 (SOD2) contributes to the stabilization of HIF-1a under hypoxia due to the decreased dismutation of superoxide radical ... We found that both stabilization of HIF-1a expression under nomoxia caused by pVHL deficiency and hypoxia treatment significantly reduced SOD2 expression, and shRNAs specifically against HIF-1a restored SOD2 expression in both circumstances