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SETD2 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → SETD2 (transcriptional regulation, unknown)
  Evidence: DNABINDING

Text-mined interactions from Literome

Miki et al., J Biol Chem 2004 (Anoxia) : However, HIF-1 alone was not sufficient to activate transcription in hypoxic conditions but, rather, required Sp1/Sp3 , which binds to a cluster of GC-rich sequences adjacent to the HRE
Woo et al., J Cereb Blood Flow Metab 2012 (Disease Models, Animal...) : Surprisingly, a series of luciferase reporter assays studying the Abcc8 promoter revealed that binding sites for specificity protein 1 (Sp1) , but not for HIF, were required for stimulation of Abcc8 transcription by HIF1a
Jeong et al., Biochem Biophys Res Commun 2012 (Prion Diseases) : This report is the first study demonstrating that HIF-1a mediated SP1 expression regulates PrPc transcription, and upregulation of SP1 induced by HIF-1a plays a key role in protection from prion mediated neurotoxicity
Biswas et al., PloS one 2013 : Mutation analyses, electrophoretic mobility shift assay and chromatin immunoprecipitation assay confirm the role of Sp1 in HIF-1a transcription ... We further demonstrate that insulin induced ROS generation initiates signaling pathway involving phosphatidylinositol 3-kinase and protein kinase C for Sp1 mediated HIF-1a transcription