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SREBF1 — SYTL4
Text-mined interactions from Literome
Kato et al., Cell Metab 2006
(Diabetes Mellitus, Experimental) :
Granuphilin is
activated by
SREBP-1c and involved in impaired insulin secretion in diabetic mice
Oberkofler et al., J Mol Med (Berl) 2009
(Insulinoma) :
Furthermore PGC-1beta,
SREBP-1c , and FOXA2 overexpression
augmented granuphilin promoter activity, whereas siRNA mediated gene knockdown of PGC-1beta reduced the effects of SREBP-1c and FOXA2 on granuphilin gene transcription and significantly increased glucose stimulated insulin release from INS-1E cells