Gene interactions and pathways from curated databases and text-mining

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IL4 — SMAD3

Text-mined interactions from Literome

Verrecchia et al., J Biol Chem 2003 : We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ), interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not inhibit the formation of SMAD-DNA complexes and the resulting SMAD-driven transcription in response to TGF-beta
Leonardi et al., Clin Exp Allergy 2011 (Conjunctivitis, Allergic) : In conjunctival fibroblast cultures, Smad-3 and PIP were stimulated by histamine, IL-4 , -13 and TGF-ß1 exposure, while PIP was reduced by IFN-?, and TNF-a mRNA expression of Smad-3 was increased by histamine, while Smad-7 was reduced by IL-4