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CDKN1A — PPARG

Text-mined interactions from Literome

Wakino et al., J Biol Chem 2001 : PPARgamma ligands regulate p21 ( Cip1 ) at a post-translational level by blocking PKCdelta signaling and accelerating p21 ( Cip1 ) turnover
Han et al., Clin Cancer Res 2004 (Lung Neoplasms) : In this study, we explored the role of PPARgamma signaling on the control of gene expression of the cycle dependent kinase inhibitor p21 in human lung carcinoma cells ... The induction of p21 gene expression by PPARgamma ligands may be mediated through increased Sp1- and NF-IL6 ( C/EBP ) -dependent transcriptional activation
Jarvis et al., Oncogene 2005 : Both PPARgamma and PPARdelta influence sulindac sulfide mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line
Lei et al., Mol Cancer Ther 2006 (Ovarian Neoplasms) : DIM-C-pPhtBu also inhibits G0-G1 to S phase cell cycle progression and this is linked, in part, to PPARgamma dependent induction of the cyclin dependent kinase inhibitor p21
York et al., Clin Cancer Res 2007 (Carcinoma, Renal Cell...) : PPARgamma is overexpressed in ACHN cells and barely detectable in 786-0 cells, and treatment with DIM-C-pPhtBu induces proteasome dependent degradation of cyclin D1 and variable effects on p21 and p27 expression in both cell lines
Dubourdeau et al., Eur Cytokine Netw 2008 : Opposite roles of STAT and PPARgamma in the induction of p21WAF1 expression by IL-13 in human peripheral blood monocytes ... We found that inhibition of PPARgamma increases IL-13 induced p21WAF1 gene expression in these models
Rageul et al., Int J Cancer 2009 (Colonic Neoplasms) : We also demonstrate that PPARgamma activation leads to increased ( p21WAF1/Cip1 and keratin 19 ) or decreased ( cyclin D1 ) expression of known KLF4 targets, suggesting that KLF4 is a nodal player in a network of PPARgamma regulated genes