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PARP1 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → PARP1 (transcriptional regulation, unknown)
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PARP1 — SP1 (physical association, affinity chromatography technology) Zaniolo et al., BMC molecular biology 2007*
• IRef Biogrid Interaction: PARP1 — SP1 (direct interaction, enzymatic study) Zaniolo et al., BMC molecular biology 2007*
• IRef Intact Interaction: Complex of 248 proteins (association, pull down) von Eyss et al., EMBO J 2012

Text-mined interactions from Literome

Guo et al., Gene 2013 : In addition, we found that Poly [ADP-ribose] polymerase 1 (PARP1) binds to the palindromic sequence TCTCGCGAGA in the ultraconserved region of the FBN1 promoter and that the regulation of FBN1 expression by PARP1 is dependent on Sp1
Laniel et al., Biochem Cell Biol 1997 : The GC-rich nature of its upstream gene promoter, along with the lack of TATA and CAAT boxes, a feature common to most housekeeping genes, is consistent with a major regulatory function played by the positive transcription factor Sp1 in rat PARP gene transcription