UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to RHOA

ARHGDIA — RHOA

Pathways - manually collected, often from reviews:

KEGG Neurotrophin signaling pathway: ARHGDIA/ARHGDIB → RHOA (protein-protein, activation)
NCI Pathway Database Regulation of RhoA activity: RHOGDI (ARHGDIA) → RHOA/GTP complex (RHOA) (modification, collaborate) Hancock et al., EMBO J 1993 *
Evidence: assay, physical interaction
NCI Pathway Database Regulation of RhoA activity: RHOGDI (ARHGDIA) → RhoA/GTP/RHOGDI complex (RHOA-ARHGDIA) (modification, collaborate)
Hancock et al., EMBO J 1993 *
Evidence: assay, physical interaction
NCI Pathway Database Regulation of RhoA activity: RHOA/GTP complex (RHOA) → RhoA/GTP/RHOGDI complex (RHOA-ARHGDIA) (modification, collaborate)
Hancock et al., EMBO J 1993 *
Evidence: assay, physical interaction
NCI Pathway Database PAR1-mediated thrombin signaling events: RHOGDI (ARHGDIA) → RHOA/GDP complex (RHOA) (modification, collaborate) Singh et al., J Biol Chem 2007 *
Evidence: assay
NCI Pathway Database PAR1-mediated thrombin signaling events: RHOGDI (ARHGDIA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Singh et al., J Biol Chem 2007 *
Evidence: assay
NCI Pathway Database PAR1-mediated thrombin signaling events: PKC alpha (PRKCA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, activates)
Singh et al., J Biol Chem 2007 *
Evidence: assay
NCI Pathway Database PAR1-mediated thrombin signaling events: RHOA/GDP complex (RHOA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Singh et al., J Biol Chem 2007 *
Evidence: assay
NCI Pathway Database Regulation of RhoA activity: RHOGDI (ARHGDIA) → RHOA/GDP complex (RHOA) (modification, collaborate) Hancock et al., EMBO J 1993 *
Evidence: assay, physical interaction
NCI Pathway Database Regulation of RhoA activity: RHOGDI (ARHGDIA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Hancock et al., EMBO J 1993 *
Evidence: assay, physical interaction
NCI Pathway Database Regulation of RhoA activity: RHOA/GDP complex (RHOA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Hancock et al., EMBO J 1993 *
Evidence: assay, physical interaction
NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: RHOA/GTP complex (RHOA) → MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) (modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: RHOA/GTP complex (RHOA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) → None (modification, collaborate) Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) → None (modification, collaborate) Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
Reactome Reaction: ARHGDIA → RHOA (reaction) Scheffzek et al., Nat Struct Biol 2000, Hoffman et al., Cell 2000, Robbe et al., J Biol Chem 2003, Yamashita et al., Nat Neurosci 2003, Hart et al., Science 1992, Sun et al., J Biol Chem 2004, DerMardirossian et al., Trends Cell Biol 2005, Bächner et al., Hum Mol Genet 1995, Adra et al., Proc Natl Acad Sci U S A 1997, Gosser et al., Nature 1997
Reactome Reaction: ARHGDIA → RHOA (indirect_complex) Scheffzek et al., Nat Struct Biol 2000, Hoffman et al., Cell 2000, Yamashita et al., Nat Neurosci 2003, Hart et al., Science 1992, Gehler et al., J Neurosci 2004 *, Sun et al., J Biol Chem 2004, DerMardirossian et al., Trends Cell Biol 2005, Bächner et al., Hum Mol Genet 1995, Adra et al., Proc Natl Acad Sci U S A 1997, Gosser et al., Nature 1997, Keep et al., Structure 1997 *

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind Interaction: RHOA — ARHGDIA Longenecker et al., Acta Crystallogr D Biol Crystallogr 1999 *, Gosser et al., Nature 1997, Keep et al., Structure 1997 *, Wei et al., Nat Struct Biol 1997 *, Ihara et al., J Biol Chem 1998 *
IRef Bind_translation Interaction: RHOA — ARHGDIA (x-ray crystallography) Gosser et al., Nature 1997
IRef Biogrid Interaction: RHOA — ARHGDIA (physical association, affinity chromatography technology) Ewing et al., Molecular systems biology 2007
IRef Biogrid Interaction: RHOA — ARHGDIA (physical association, affinity chromatography technology) Man et al., J Clin Invest 2010 *
IRef Biogrid Interaction: RHOA — ARHGDIA (physical association, affinity chromatography technology) Michaelson et al., J Cell Biol 2001 *
IRef Biogrid Interaction: RHOA — ARHGDIA (association, biochemical) Gajate et al., J Biol Chem 2005
IRef Biogrid Interaction: RHOA — ARHGDIA (association, biochemical) Gorvel et al., FEBS Lett 1998 *
IRef Biogrid Interaction: RHOA — ARHGDIA (direct interaction, two hybrid) Fauré et al., Biochimie 2001 *
IRef Hprd Interaction: RHOA — ARHGDIA (in vivo) Longenecker et al., Acta Crystallogr D Biol Crystallogr 1999 *
IRef Hprd Interaction: RHOA — ARHGDIA (in vitro) Longenecker et al., Acta Crystallogr D Biol Crystallogr 1999 *
IRef Intact Interaction: RHOA — ARHGDIA (physical association, anti bait coimmunoprecipitation) Ewing et al., Molecular systems biology 2007
IRef Intact Interaction: RHOA — ARHGDIA (direct interaction, x-ray crystallography) Longenecker et al., Acta Crystallogr D Biol Crystallogr 1999 *
IRef Intact Interaction: RHOA — ARHGDIA (physical association, anti bait coimmunoprecipitation) Wang et al., Asian J Androl 2010 *
IRef Ophid Interaction: RHOA — ARHGDIA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
IRef Ophid Interaction: RHOA — ARHGDIA (aggregation, confirmational text mining) Michaelson et al., J Cell Biol 2001 *

Text-mined interactions from Literome

Dovas et al., J Biol Chem 2010 : Here, it is demonstrated that conventional PKC phosphorylates RhoGDIalpha on serine 34, resulting in a specific decrease in affinity for RhoA but not Rac1 or Cdc42
Sabbatini et al., PloS one 2013 : RhoA translocation is also inhibited by RhoGDI1