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TCF7L2 — WNT3
Text-mined interactions from Literome
Shulewitz et al., Oncogene 2006
(Breast Neoplasms) :
Repressor
roles for
TCF-4 and Sfrp1 in
Wnt signaling in breast cancer ... Our results indicate that both Sfrp1 and
TCF-4 repress
Wnt signaling in breast tissue and their downregulation contributes to the activation of Wnt signaling
Carroll-Anzinger et al., J Virol 2007
:
Given that
TCF-4 is the downstream
effector of
Wnt signaling, harnessing Wnt signaling as an intrinsic molecular mechanism to limit HIV replication may emerge as a powerful tool to regulate HIV replication within and outside of the brain
Liu et al., Adv Exp Med Biol 2010
(Diabetes Mellitus, Type 2) :
Beta-catenin/TCF7L2 dependent
Wnt signaling ( the canonical pathway ) is involved in pancreas development, islet function, and insulin production and secretion
Zhang et al., Cell Signal 2010
:
Dishevelled-DEP domain interacting protein ( DDIP )
inhibits Wnt signaling by promoting TCF4 degradation and disrupting the
TCF4/beta-catenin complex
Cole et al., Cancer Res 2010
(Adenoma...) :
Inactivation of the Apc gene is recognized as the key early event in the development of sporadic colorectal cancer ( CRC ), where its loss leads to constitutive
activation of
ß-catenin/T-cell factor 4 signaling and hence transcription of
Wnt target genes such as c-Myc
Ravindranath et al., Br J Cancer 2011
(Breast Neoplasms...) :
Our results suggest that
Tcf-4 can act as a repressor or activator of breast cancer progression by regulating OPN expression in a
Wnt dependent manner and that Tcf-4 and OPN together may be a novel prognostic indicator for breast cancer progression
Li et al., Proc Natl Acad Sci U S A 2012
(Diabetes Mellitus, Type 2) :
Mutations in Wnt receptor LRP5/6 and polymorphism in
Wnt regulated transcription factor
TCF7L2 are associated with dysregulation of glucose metabolism
Ip et al., Am J Physiol Endocrinol Metab 2012
(Wnt Signaling Pathway) :
As carriers of TCF7L2 type 2 diabetes risk SNPs demonstrated increased hepatic glucose production, we aimed to determine whether
TCF7L2 expression is regulated by nutrient availability and whether TCF7L2 and
Wnt regulate hepatic gluconeogenesis
Zhang et al., Bone 2013
:
Activation of
Wnt signaling by Wnt3a or overexpression of
ß-catenin/TCF4 both stimulated BMP2 transcription at promoter and mRNA levels