Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — RSPO1

Text-mined interactions from Literome

Kazanskaya et al., Dev Cell 2004 : R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
Wei et al., J Biol Chem 2007 : R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling
Chassot et al., Hum Mol Genet 2008 : Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary ... beta-catenin activation is controlled by Rspo1 in XX gonads and Rspo1 knockout mice show masculinized gonads
Tamashiro et al., Biochim Biophys Acta 2008 : By contrast, female sex determination depends on the action of Rspo1 and Wnt4, the regulators of Wnt/beta-catenin signaling
Lu et al., Biochemistry 2010 : Mesd not only blocks binding of Wnt antagonists Dkk1 and Sclerostin to LRP5 and LRP6 but also inhibits Wnt3A and Rspondin1 induced Wnt/beta-catenin signaling in LRP5- and LRP6 expressing cells