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ABL1 — ATM

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ABL1 → ATM (directlyIncreases, ABL1 Activity) Baskaran et al., Nature 1997*
  Evidence: from full text - Fig 2 and 3 - ATM kinase activates c-Abl kinase. Serine-465 of c-Abl is required for tyrosine kinase activation by ionizing radiation and ATM. 3T3 cells
• BioCarta atm signaling pathway: ATR/ATRIP/ATM complex (ATR-TREX1-ATM) → c-ABL (ABL1) (modification, activates)
• NCI Pathway Database ATM pathway: ATM (ATM) → c-Abl (ABL1) (modification, activates) Shangary et al., J Biol Chem 2000*, Baskaran et al., Nature 1997*, Shafman et al., Nature 1997*
  Evidence: mutant phenotype, physical interaction
• WikiPathways TP53 Network: ATM → ABL1 (activation) Shaul et al., Cell Death Differ 2000*
• WikiPathways ATM Signaling Pathway: ATM → ABL1 (mim-stimulation)
• WikiPathways DNA Damage Response (only ATM dependent): ATM → ABL1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ATM — ABL1 (direct interaction, two hybrid) Shafman et al., Nature 1997*
• IRef Biogrid Interaction: ATM — ABL1 (direct interaction, enzymatic study) Hunt et al., Cancer Res 2007*
• IRef Biogrid Interaction: ATM — ABL1 (physical association, affinity chromatography technology) Wang et al., Cell Death Differ 2011*
• IRef Biogrid Interaction: ATM — ABL1 (physical association, affinity chromatography technology) Chen et al., J Biol Chem 1999*
• IRef Biogrid Interaction: ATM — ABL1 (physical association, affinity chromatography technology) Kishi et al., J Biol Chem 2001*
• IRef Biogrid Interaction: ATM — ABL1 (physical association, affinity chromatography technology) Shafman et al., Nature 1997*
• IRef Biogrid Interaction: ATM — ABL1 (direct interaction, pull down) Shafman et al., Nature 1997*
• IRef Hprd Interaction: ABL1 — ATM (in vitro) Baskaran et al., Nature 1997*, Shafman et al., Nature 1997*
• IRef Hprd Interaction: ABL1 — ATM (in vivo) Baskaran et al., Nature 1997*, Shafman et al., Nature 1997*
• IRef Hprd Interaction: ABL1 — ATM (two hybrid) Baskaran et al., Nature 1997*, Shafman et al., Nature 1997*
• IRef Intact Interaction: ATM — ABL1 (physical association, anti bait coimmunoprecipitation) Kishi et al., J Biol Chem 2001*
• IRef Ophid Interaction: ATM — ABL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Takao et al., J Biol Chem 2000 (Ataxia Telangiectasia) : c-Abl is activated by DNA damage in an ataxia telangiectasia mutated (ATM) dependent manner and plays important roles in growth arrest and apoptosis induced by DNA damage
Wang et al., Cell Death Differ 2011 : A positive role for c-Abl in Atm and Atr activation in DNA damage response ... Indeed, we found that c-Abl is required for proper activation of both Atm and Atr ... These findings suggest that Atm mediated c-Abl activation in cell response to double stranded DNA breaks might facilitate the activation of both Atm and Atr to regulate their downstream cellular events
Tang et al., Chembiochem 2012 : Previous studies have established that ataxia telangiectasia mutated (ATM) activates nuclear Abl by phosphorylating serine 465 ( S465 ) in the kinase domain in response to ionizing radiation ( IR )
Wang et al., International journal of biomedical science : IJBS 2007 : Atm also activates c-Abl , a non-receptor tyrosine kinase, to promote apoptosis
Kharbanda et al., Oncogene 1998 : The DNA dependent protein kinase (DNA-PK) and the ataxia telangiectasia mutated (ATM) gene product, effectors in the DNA damage response, contribute to the induction of c-Abl activity
Kharbanda et al., Oncogene 1998 : The ataxia telangiectasia mutated (ATM) gene product also contributes to c-Abl activation