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GAB2 — JAK2
Pathways - manually collected, often from reviews:
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NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
GRB2/GAB2 complex (GRB2-GAB2)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GRB2/GAB2 complex (GRB2-GAB2)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
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Reactome Reaction:
JAK2
→
GAB2
(indirect_complex)
Text-mined interactions from Literome
Tao et al., Oncogene 2008
(Cell Transformation, Neoplastic) :
The Bcr-Abl kinase inhibitor imatinib mesylate ( 1 microM ) and two
Jak2 kinase inhibitors strongly
inhibited agar colony formation and the activation of
Gab2 caused by Jak2
Wang et al., Cell Signal 2008
:
G-CSF stimulates
Jak2 dependent
Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation ... Together, these results identify a novel signaling pathway involving
Jak2 dependent
Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation in response to G-CSF