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AHR — IRF6
Text-mined interactions from Literome
Held et al., Am J Respir Crit Care Med 2000
(Bronchial Hyperreactivity) :
Blockade of the thromboxane/endoperoxide ( TP ) receptor with SQ29.548 completely protected against
LPS induced
AHR and VHR ... Blockade of cyclooxygenase-2 (COX-2) abolished LPS induced VHR but suppressed
LPS induced
AHR only marginally ... Pretreatment with the radical scavenger N-acetylcysteine partly protected against
LPS induced
AHR ... Our findings show that
LPS induces
AHR and VHR in mouse lungs via activation of the TP receptor
Toward et al., J Pharmacol Exp Ther 2001
(Pneumonia) :
Dexamethasone ( 20 mg x kg ( -1 ) i.p. ) or rolipram ( 1 mg x kg ( -1 ) i.p. ) prevented single and chronic
LPS induced
AHR , the respective deficiency and elevation in NO metabolites, and the chronic LPS induced leukocyte influx ... This study demonstrates for the first time that chronic
LPS causes persistent bronchoconstriction, neutrophilic inflammation,
AHR , and NO overproduction in guinea pig airways
Jiang et al., Inflamm Res 2006
(Asthma...) :
Our results demonstrate that repetitive intraperitoneal
LPS can
induce persistent
AHR which occurs earlier when the frequency of injection increase, and an elevation of NO production and iNOS activity may be involved in is systemic-LPS induced AHR
Jiang et al., Chin Med J (Engl) 2008
(Bronchial Hyperreactivity) :
This study aimed to determine whether their alteration also plays an important role in the
AHR induced by
lipopolysaccharide (LPS) ... The data suggest that inducible NOS contributes to the
AHR induced by repetitive intraperitoneal
LPS , and constitutive NOS was also involved
Sekine et al., Mol Cell Biol 2009
(Shock, Septic) :
Analysis of gene expression revealed that
AhR directly regulates the expression of Pai-2 through a mechanism involving NF-kappaB but not AhR nuclear translocator (Arnt), in an
LPS dependent manner
Nguyen et al., Proc Natl Acad Sci U S A 2010
:
Here, we show that
lipopolysaccharide (LPS) and CpG
stimulate Ahr expression in bone marrow derived dendritic cells ( BMDC )
Tsuchiya et al., Am J Physiol Lung Cell Mol Physiol 2012
(Airway Remodeling...) :
The presence of
LPS in OVA inhalations
affects airway inflammation and
AHR but not remodeling in a rodent model of asthma
Choi et al., Pediatr Res 2013
:
Intra-amniotic
LPS further
increased hyperoxia induced
AHR but did not further impair respiratory system compliance