Gene interactions and pathways from curated databases and text-mining

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AHR — IRF6

Text-mined interactions from Literome

Held et al., Am J Respir Crit Care Med 2000 (Bronchial Hyperreactivity) : Blockade of the thromboxane/endoperoxide ( TP ) receptor with SQ29.548 completely protected against LPS induced AHR and VHR ... Blockade of cyclooxygenase-2 (COX-2) abolished LPS induced VHR but suppressed LPS induced AHR only marginally ... Pretreatment with the radical scavenger N-acetylcysteine partly protected against LPS induced AHR ... Our findings show that LPS induces AHR and VHR in mouse lungs via activation of the TP receptor
Toward et al., J Pharmacol Exp Ther 2001 (Pneumonia) : Dexamethasone ( 20 mg x kg ( -1 ) i.p. ) or rolipram ( 1 mg x kg ( -1 ) i.p. ) prevented single and chronic LPS induced AHR , the respective deficiency and elevation in NO metabolites, and the chronic LPS induced leukocyte influx ... This study demonstrates for the first time that chronic LPS causes persistent bronchoconstriction, neutrophilic inflammation, AHR , and NO overproduction in guinea pig airways
Jiang et al., Inflamm Res 2006 (Asthma...) : Our results demonstrate that repetitive intraperitoneal LPS can induce persistent AHR which occurs earlier when the frequency of injection increase, and an elevation of NO production and iNOS activity may be involved in is systemic-LPS induced AHR
Jiang et al., Chin Med J (Engl) 2008 (Bronchial Hyperreactivity) : This study aimed to determine whether their alteration also plays an important role in the AHR induced by lipopolysaccharide (LPS) ... The data suggest that inducible NOS contributes to the AHR induced by repetitive intraperitoneal LPS , and constitutive NOS was also involved
Sekine et al., Mol Cell Biol 2009 (Shock, Septic) : Analysis of gene expression revealed that AhR directly regulates the expression of Pai-2 through a mechanism involving NF-kappaB but not AhR nuclear translocator (Arnt), in an LPS dependent manner
Nguyen et al., Proc Natl Acad Sci U S A 2010 : Here, we show that lipopolysaccharide (LPS) and CpG stimulate Ahr expression in bone marrow derived dendritic cells ( BMDC )
Tsuchiya et al., Am J Physiol Lung Cell Mol Physiol 2012 (Airway Remodeling...) : The presence of LPS in OVA inhalations affects airway inflammation and AHR but not remodeling in a rodent model of asthma
Choi et al., Pediatr Res 2013 : Intra-amniotic LPS further increased hyperoxia induced AHR but did not further impair respiratory system compliance