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GATA2 — IRF6
Text-mined interactions from Literome
Simoncini et al., Circ Res 2000
:
Consistently, gel-shift assays showed that E ( 2 ) and Dex comparably inhibit LPS induced activation of NF-kappaB, whereas E ( 2 ) inhibited
LPS induced activation of AP-1 and
GATA to a greater extent than Dex
El Gazzar et al., Inflamm Res 2007
:
Chromatin immunoprecipitation revealed that GATA, AP-1 and NF-AT binding to IL-5 promoter was induced by
LPS stimulation and that TQ
inhibited GATA binding at the IL-5 promoter but did not affect AP-1 and NF-AT binding
Wu et al., PloS one 2013
:
GATA-2 Transduces
LPS Induced il-1ß Gene Expression in Macrophages via a Toll-Like Receptor 4/MD88/MAPK-Dependent Mechanism ...
LPS could
enhance the transactivation activity of
GATA-2 in macrophages ... Sequentially, treatment with myeloid differentiation factor 88 ( MyD88 ) siRNA decreased
LPS induced phosphorylation of mitogen activated protein kinases ( MAPKs ) kinase 1/2 and subsequent translocation of
GATA-2 ... Results of this study show that
LPS induction of il-1ß gene expression in macrophages is
mediated by
GATA-2 via activation of TLR4, MyD88, and MAPKs