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IRF6 — SERPING1

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Liu et al., J Immunol 2003 (Disease Models, Animal...) : Both forms of C1INH blocked the LPS binding protein dependent binding of Salmonella typhimurium LPS to the murine macrophage cell line, RAW 264.7, and suppressed LPS induced TNF-alpha mRNA expression
Liu et al., Blood 2005 (Shock, Septic) : As illustrated by laser scanning confocal microscopy, C1INH completely blocked the binding of fluorescein isothiocyanate ( FITC ) -LPS to human umbilical vein endothelial cells ( HUVECs )
Liu et al., Infect Immun 2005 : The C1INH mutants that did not bind to LPS also did not suppress LPS binding or LPS induced up-regulation of tumor necrosis factor alpha mRNA expression in RAW 264.7 macrophages
Landsem et al., Clin Exp Immunol 2013 (Sepsis) : C1-INH ( 1·25-5 mg/ml ) reduced both LPS- and E.?coli induced coagulation, measured as a reduction of PTF1·2 in plasma, efficiently and dose-dependently ( P < 0·05 )