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IRS2 — STAT6
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
STAT6 (dimer) complex (STAT6)
(T-helper 2 cell differentiation, activates)
Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Inoue et al., J Biochem 2007
:
Tyrosine phosphorylation, and thereby the activation of Stat6 and IRS-2, is critical for IL-4 signalling ; however, only the activation of
Stat6 , not the
IRS-2 dependent phosphorylation of Akt, was perturbed in Dok-1-deficient cells stimulated with IL-4
White et al., Am J Physiol Lung Cell Mol Physiol 2009
:
This reparative response does not require
STAT6 activation, but rather
requires IRS-1 and/or
IRS-2