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ADCYAP1 — PLD4
Text-mined interactions from Literome
Dejda et al., Ann N Y Acad Sci 2006
:
Their effects on PLC-IP3/DAG were weaker, while only
PACAP and VIP ( 0.1-5 microM ) significantly
stimulated PLD activity
Morisset et al., Cell Signal 1995
(Pancreatic Neoplasms) :
PACAP-38 and -27
caused a dose dependent and parallel activation of tyrosine kinase and
PLD an effect prevented by the antagonist PACAP 7-38 ... Finally,
PACAP stimulated tyrosine kinase and
PLD activities are both inhibited by cell 's preincubation with genistein and pertussis toxin ...
PACAP can
induce concomitant activation of tyrosine kinase and
PLD ; this finding and the observation that inhibition of these two enzymes inhibited PACAP induced AR4-2J cell growth strongly suggests that they are intimately involved in the overall process of PACAP induced AR4-2J cell proliferation