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FOS — SERPINE1

Text-mined interactions from Literome

Ahn et al., Diabetologia 2001 : We evaluated the role of AP-1 in PAI-1 gene expression in human vascular smooth muscle cells under high D-glucose and Ang II stimulation using a double stranded cis-element AP-1 oligodeoxynucleotide ( decoy ODN ) ... These data indicate an important role for AP-1 in PAI-1 expression
Andrew et al., Am J Physiol Lung Cell Mol Physiol 2001 : Addition of nickel to BEAS-2B human airway epithelial cells stimulated intracellular oxidation, induced c-Jun and c-Fos mRNA levels, increased phospho- and total c-Jun protein levels, and elevated PAI-1 mRNA levels over a 24-h time course ... These data indicated that nickel activated AP-1 through an oxidant independent pathway and that basal AP-1 is necessary for nickel induced expression of PAI-1
Vayalil et al., Am J Physiol Lung Cell Mol Physiol 2007 : Decoy oligonucleotides ( ODN ) studies further demonstrate that AP-1 , SP-1, and Smad ODNs abrogate the inhibitory effect of GSH on TGF-beta induced PAI-1 promoter activity and inhibit TGF-beta induced expression of endogenous PAI-1
Geh et al., Proc Natl Acad Sci U S A 2011 (MAP Kinase Signaling System) : The second network is initiated by the enzymatic activity of MAP3K1, which phosphorylates and activates a JNK-c-Jun module, leading to AP-1 transactivation and induction of its downstream genes, such as Pai-1
Sundqvist et al., Oncogene 2013 (Breast Neoplasms...) : Finally, chromatin immunoprecipitations showed that c-Jun, JunB and Fra1, but not c-Fos , are required for TGFß induced binding of Smad2/3 to the mmp-10 and pai-1 promoters
Arts et al., Eur J Biochem 1996 : An essential role of c-Jun and c-Fos in basal and PMA stimulated transcription of the PAI-1 gene is demonstrated by our finding that antisense c-jun and c-fos oligodeoxynucleotides both strongly reduced basal and PMA stimulated PAI-1 synthesis