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MT2A — UCP1

Text-mined interactions from Literome

Cettour-Rose et al., Endocrinology 2002 (Body Weight...) : In lean rats, MTII prevented the decrease in brown adipose tissue UCP1 , UCP2, and UCP3 expression and muscle UCP3 occurring during food restriction
Williams et al., Endocrinology 2003 (Decerebrate State) : A second experiment demonstrated that the fourth i.c.v. MTII induced rise in UCP-1 expression was mediated by sympathetic outflow to BAT by showing that this response was abolished by surgical denervation of BAT ... Taken together, the results indicate that : 1 ) there is an independent caudal brainstem MC3/4-R trigger for a sympathetically stimulated elevation in BAT UCP-1 gene expression, and 2 ) the MTII induced rise in UCP-1 expression can be mediated by circuitry intrinsic to the caudal brainstem and spinal cord