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IL12B — NM

Text-mined interactions from Literome

Moreno et al., J Immunol 2006 (Sepsis) : IL-12 and IL-18 play an important role in neutrophil migration ... IL-12 acts through induction of IFN-gamma and stimulation of phagocytic and microbicidal activities of neutrophils, rather than neutrophil migration per se
Lemos et al., Proc Natl Acad Sci U S A 2009 (Arthritis, Rheumatoid...) : Prostaglandin mediates IL-23/IL-17 induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production ... Here we report that prostaglandin enhances the IL-23/IL-17 induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN gamma production ... Methylated BSA ( mBSA ) and IL-23 induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-17 antibodies, COX inhibitors, IL-12 , or IFNgamma but was enhanced by prostaglandin E ( 2 ) ( PGE ( 2 ) ) ... Methylated BSA ( mBSA ) and IL-23 induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-17 antibodies, COX inhibitors, IL-12, or IFNgamma but was enhanced by prostaglandin E ( 2 ) ( PGE ( 2 ) ) ... Furthermore, COX inhibition failed to reduce IL-23 induced neutrophil migration in IL-12- or IFNgamma-deficient mice ... IL-17 induced neutrophil migration was not affected by COX inhibitors, IL-12 , or IFNgamma but was inhibited by MK886 ( a leukotriene synthesis inhibitor ), anti-TNFalpha, anti-CXCL1, and anti-CXCL5 antibodies and by repertaxin ( a CXCR1/2 antagonist ) ... These treatments all inhibited mBSA- or IL-23 induced neutrophil migration ... Our results suggest that prostaglandin plays an important role in IL-23 induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNgamma production ... Our results suggest that prostaglandin plays an important role in IL-23 induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNgamma production