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EPHB2 — IFNG

Text-mined interactions from Literome

Takaoka et al., EMBO J 1999 : Overexpression of PKM, a dominant interfering form of Pyk2, in NIH 3T3 cells results in a strong inhibition of the IFN-gamma induced activation of Erk2 , serine phosphorylation of Stat1 and Stat1 dependent gene transcription
Wang et al., Hypertension 1999 (MAP Kinase Signaling System) : Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase ( ERK ), p38 MAPK, and c-Jun N-terminal kinase activity in a rapid and transient manner, whereas interferon-gamma (IFN-gamma) can induce only ERK
Hu et al., J Biol Chem 2001 (MAP Kinase Signaling System) : ERK1 and ERK2 activate CCAAAT/enhancer binding protein-beta dependent gene transcription in response to interferon-gamma
Han et al., Neurosci Lett 2002 : In contrast, IFN - gamma activated only ERK after 6 h of stimulation and did not alter the activity of p38 and JNK
Blanchette et al., Immunology 2003 (Translocation, Genetic) : To determine whether the inhibitory effect was taking place at the pre- and/or post-transcriptional level, we evaluated the effect of each antagonist on inducible nitric oxide synthase (iNOS) gene and protein expression, and on the capacity of IFN-gamma to induce JAK2, Erk1/Erk2 and STAT1alpha phosphorylation
Han et al., J Neurosci Res 2003 : PMA and IFN-gamma synergistically enhanced activity of NF-kappaB, but not ERK
Gendron et al., J Neurochem 2003 : BzATP, a potent P2X7 receptor agonist, was more effective than ATP, ADP, or 2-MeSATP at enhancing IFN gamma induced ERK1/2 phosphorylation
Song et al., J Biol Chem 2005 : IFN-gamma induced ERK1/2 phosphorylation and subsequently the transcription factor early gene response 1, which in turn up-regulated p35 expression and increased cyclin dependent kinase 5 (Cdk5) activity
Shen et al., Neurochem Int 2005 (Encephalitis...) : Despite the common involvement of PKCdelta, IFNgamma- but not LPS induced NO production involved extracellular signal regulated kinases ( ERK1/2 ) cascade and IFNgamma induced phosphorylation of ERK1/2 was mediated through PKC
Park et al., J Neuroimmunol 2005 : Sodium butyrate significantly repressed the phosphorylation of ERK induced by IFN-gamma , but had little effect on that induced by LPS
Saud et al., Neurotox Res 2005 : TGF-beta and IL-1beta reduced the IFN-gamma induced phosphorylation of ERK1,2 by 60 % and 40 %, respectively
Zhao et al., J Biol Chem 2006 : IFN-gamma enhanced lipopolysaccharide (LPS) induced ERK and JNK phosphorylation but had no effect on LPS induced NF-kappaB activation
Li et al., J Immunol 2006 (MAP Kinase Signaling System...) : Experiments with ERK-1/2 inhibitors demonstrated that bryostatin-1 induction of IFN- gamma and T-bet was ERK dependent and IL-12 independent
Cho et al., Glia 2007 (Alzheimer Disease...) : Taken together, our results suggest that IFN-gamma activates JAK2 and ERK1/2 and then phosphorylated STAT1 binds to the putative STAT1 binding sequences in BACE1 promoter region to modulate BACE1 protein expression in astrocytes
Koch et al., Respir Med 2007 (Asthma) : In conclusion, ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma, and ( 2 ) ERK- and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on IFNgamma release is impaired in asthma
Park et al., Int Immunopharmacol 2007 : In addition, these agents repressed the IFN-gamma induced ERK1/2 phosphorylation without affecting the Jak/STAT activities
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin induced phosphorylation of JAK2 and ERK , whereas IFN-gamma induced phosphorylation of JAK1, JAK2, and p38 MAPK
Burova et al., FEBS Lett 2007 : Furthermore, in these cells, EGFR kinase activity is essential for IFNgamma induced ERK1,2 activation
Boisvert et al., Mol Immunol 2007 : Inhibition studies indicated that activation of ERK and JNK MAPKs and PI3K/AKT are necessary for both TCR- and TCR+alpha2 beta1 integrin dependent IFN-gamma production and that Coll I increases TCR dependent activation of ERK and JNK MAPKs, and AKT
Girart et al., J Immunol 2007 (Melanoma) : Also, secretion of IFN-gamma was dependent on MEK1/ERK , p38 MAPK, p70 ( S6 ) kinase, and NF-kappaB, but not on calcineurin
Kondadasula et al., Blood 2008 : Studies with specific chemical inhibitors revealed that the activation of ERK was dependent on the activation of PI3-K, whose activation was dependent on Syk, and that sequential activation of these molecules was required for NK cell IFN-gamma production in response to FcR and IL-12 stimulation ... Retroviral transfection of ERK1 into primary human NK cells substantially increased IFN-gamma production in response to immobilized IgG and IL-12, while transfection of human NK cells with a dominant negative ERK1 abrogated IFN-gamma production ... Chemical disruption of lipid rafts inhibited ERK signaling in response to costimulation and significantly inhibited IFN-gamma production
Li et al., Int Immunopharmacol 2009 (Atherosclerosis) : Moreover, DHEA inhibited IFN-gamma induced activation of extracellular signal regulated kinase ( ERK1/2 )
Wu et al., Br J Pharmacol 2009 : LPS + IFNgamma stimulated phosphorylation of ERK , JNK and Jak2, and degradation of IkappaB, but only Jak2 phosphorylation was sensitive to tripterine ( 50-200 nM ) ... Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK) , c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Chung et al., J Pharmacol Sci 2010 (Inflammation) : In this study, alpha-viniferin at 3 - 10 microM dose-dependently inhibited interferon (IFN)-gamma induced Ser ( 727 ) phosphorylation of the signal transducer and activation of transcription-1 ( STAT-1 ), a pivotal transcription factor controlling IFN-gamma targeted genes, in RAW 264.7 macrophages, and also IFN-gamma induced activation of the extracellular signal regulated kinase ( ERK ) -1, a protein kinase upstream of the Ser ( 727 ) phosphorylation of STAT-1
Singh et al., J Biol Chem 1996 : The farnesyl transferase inhibitor BZA-5B blocked activation of ERK1/ERK2 and induction of NOS2 by IFN gamma and IL-1 beta in myocytes
Nishiya et al., FEBS Lett 1997 (Glioma) : Here we show that in C6 glioma cells, transiently expressing the dominant negative form of c-Ha-Ras ( Asn-17 ) abrogated IFN-gamma induced ERK1 and ERK2 activation ... These results indicate that p21ras and MEK1 are required for IFN-gamma induced ERK1 and ERK2 activation ... Further experiments showed that neither Asn-17 Ras expression nor concentrations of PD98059, which completely abrogated IFN-gamma induced ERK1 and ERK2 activation, affected Stat1 DNA binding activity or iNOS induction, indicating that the Ras-MAPK pathway does not appear to be involved in the activation of Stat1 and subsequent iNOS induction in C6 glioma cells
Egerton et al., Int Immunol 1998 : However, the production of IL-3 and IL-4 was only partially dependent upon ERK activation, whereas IL-5, IL-10, IFN-gamma and GM-CSF production was severely affected by diminished ERK activation
Mainiero et al., J Exp Med 1998 : Integrin mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells