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PDGFRB — RASA1

Pathways - manually collected, often from reviews:

• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → RasGAP (RASA1) (modification, collaborate) Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) (modification, collaborate)
  Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: RasGAP (RASA1) → PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) (modification, collaborate)
  Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB) (modification, collaborate)
  Schlesinger et al., Biochem J 1999
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Schlesinger et al., Biochem J 1999
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Schlesinger et al., Biochem J 1999
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → None (modification, activates) Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• Reactome Reaction: PDGFRB → RASA1 (indirect_complex) Kashishian et al., EMBO J 1992*, Kazlauskas et al., Mol Cell Biol 1992*, Heldin et al., Biochim Biophys Acta 1998
• Reactome Reaction: PDGFRB → RASA1 (reaction) Kashishian et al., EMBO J 1992*, Kazlauskas et al., Mol Cell Biol 1992*, Heldin et al., Biochim Biophys Acta 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PDGFRB — RASA1 Marengere et al., J Biol Chem 1992*, Anderson et al., Science 1990*, Larose et al., Oncogene 1993*, McGlade et al., EMBO J 1993*
• IRef Bind Interaction: PDGFRB — RASA1 Kazlauskas et al., Science 1990*
• IRef Bind Interaction: PDGFRB — RASA1 Roche et al., EMBO J 1996
• IRef Bind_translation Interaction: PDGFRB — RASA1 (affinity chromatography technology) Marengere et al., J Biol Chem 1992*, Anderson et al., Science 1990*
• IRef Bind_translation Interaction: PDGFRB — RASA1 (affinity chromatography technology) Marengere et al., J Biol Chem 1992*, Larose et al., Oncogene 1993*
• IRef Bind_translation Interaction: PDGFRB — RASA1 (affinity chromatography technology) Roche et al., EMBO J 1996
• IRef Bind_translation Interaction: PDGFRB — RASA1 (coimmunoprecipitation) Kazlauskas et al., Science 1990*
• IRef Bind_translation Interaction: PDGFRB — RASA1 (affinity chromatography technology) Marengere et al., J Biol Chem 1992*
• IRef Bind_translation Interaction: PDGFRB — RASA1 (coimmunoprecipitation) Marengere et al., J Biol Chem 1992*, McGlade et al., EMBO J 1993*
• IRef Biogrid Interaction: PDGFRB — RASA1 (physical association, affinity chromatography technology) Farooqui et al., Anticancer Res 1999*
• IRef Biogrid Interaction: PDGFRB — RASA1 (physical association, affinity chromatography technology) Ekman et al., Oncogene 2002
• IRef Dip Interaction: PDGFRB — RASA1 (physical association, biophysical) Myers et al., Ann N Y Acad Sci 1995*
• IRef Hprd Interaction: PDGFRB — RASA1 (in vivo) Farooqui et al., Anticancer Res 1999*
• IRef Intact Interaction: PDGFRB — RASA1 (association, coimmunoprecipitation) Kashishian et al., EMBO J 1992*
• IRef Intact Interaction: PDGFRB — RASA1 (association, coimmunoprecipitation) Kazlauskas et al., Mol Cell Biol 1992*
• IRef Intact Interaction: PDGFRB — RASA1 (association, coimmunoprecipitation) Cooper et al., Mol Cell Biol 1993
• IRef Ophid Interaction: PDGFRB — RASA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PDGFRB — RASA1 (aggregation, confirmational text mining) Ekman et al., Oncogene 2002

Text-mined interactions from Literome

Farooqui et al., Anticancer Res 1999 (Brain Neoplasms...) : PDGF stimulated the association of PDGFR-beta with p85, ras GTPase activating protein and PLC gamma
Newton et al., J Biol Chem 2005 : Using a panel of cytoplasmic domain mutants of the chimeric M-CSF/PDGFR-beta, we confirmed that the kinase domain of PDGFR-beta is absolutely required for LRP tyrosine phosphorylation but that PDGFR-beta mediated activation of phosphatidylinositol 3-kinase, RasGAP , SHP-2, phospholipase C-gamma, and Src are not necessary for LRP tyrosine phosphorylation
Vaillancourt et al., Mol Cell Biol 1995 : beta PDGF-R regulation of phosphatidylinositol 3-kinase, the GTPase activating protein of Ras, and the tyrosine phosphatase, Syp, was not required for PC12 cell differentiation