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B2M — CD8A

Pathways - manually collected, often from reviews:

• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → JUN (JUN) (modification, activates)
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → JNK1 (MAPK8) (modification, activates)
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: CSK/PAG1 complex (CSK-PAG1) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, collaborate)
  Brdicka et al., J Exp Med 2000
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → Csk (CSK) (modification, activates) Brdicka et al., J Exp Med 2000
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, collaborate)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → LCK (LCK) (modification, collaborate) Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, activates)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: LCK (LCK) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → SHC (SHC1) (modification, activates) Walk et al., Eur J Immunol 1998
  Evidence: expresssion pattern
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → Perforin 1 (PRF1) (transcription, activates) Curtsinger et al., J Exp Med 2003
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → B7 family/CD28 complex (CD28-CD80_CD86) (transcription, activates)
  Curtsinger et al., J Exp Med 2003
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → Monovalent TCR/CD3 complex (CD247-CD3E-CD3G-CD3D) (modification, collaborate)
  Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → CD8 heterodimer complex (CD8A-CD8B) (modification, collaborate)
  Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → peptide-MHC class I complex (HLA-A-B2M) (modification, collaborate)
  Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: CD8 heterodimer complex (CD8A-CD8B) → peptide-MHC class I complex (HLA-A-B2M) (modification, collaborate)
  Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: CBL (CBL) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, collaborate)
  Davanture et al., J Immunol 2005
  Evidence: mutant phenotype, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: CBL (CBL) → TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL) (modification, collaborate)
  Davanture et al., J Immunol 2005
  Evidence: mutant phenotype, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL) (modification, collaborate)
  Davanture et al., J Immunol 2005
  Evidence: mutant phenotype, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: LAT/GRAP2/SLP76/VAV1 complex (LAT-GRAP2-LCP2-VAV1) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
  Reynolds et al., J Exp Med 2002, Fukazawa et al., J Biol Chem 1995, Carrera et al., J Biol Chem 1994, Exley et al., J Biol Chem 1994, de Aós et al., J Biol Chem 1997, Zhang et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL2 (IL2) (modification, activates)
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL2R complex (IL2RA-IL2RB-IL2RG) (modification, activates)
  
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, activates)
  
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL2R gamma (IL2RG) (modification, activates) Akbar et al., Eur J Immunol 1996
  Evidence: mutant phenotype
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL2R gamma cytokines/IL2R gamma complex (IL2RG) (modification, activates)
  Akbar et al., Eur J Immunol 1996
  Evidence: mutant phenotype
• NCI Pathway Database IL12-mediated signaling events: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → EOMES (EOMES) (transcription, activates) Takemoto et al., J Immunol 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL12-mediated signaling events: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (transcription, activates)
  Takemoto et al., J Immunol 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → Fyn (FYN) (modification, collaborate) van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → TCR/CD3/MHC I/CD8/Fyn complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-FYN) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: Fyn (FYN) → TCR/CD3/MHC I/CD8/Fyn complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-FYN) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → ZAP-70 (ZAP70) (modification, collaborate) Iwashima et al., Science 1994
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
  Iwashima et al., Science 1994
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, activates)
  Iwashima et al., Science 1994
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: ZAP-70 (ZAP70) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
  Iwashima et al., Science 1994
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: LAT/GRAP2/SLP76/VAV1/PI3K Class IA complex (LAT-GRAP2-LCP2-VAV1) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, activates)
  Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
  Evidence: mutant phenotype, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → PKC theta (PRKCQ) (modification, activates) Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
  Evidence: mutant phenotype, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, activates) Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
  Evidence: mutant phenotype, other species
• Reactome Reaction: B2M → CD8A (reaction) Kjer-Nielsen et al., Proc Natl Acad Sci U S A 2004, Arnett et al., Proc Natl Acad Sci U S A 2004, Rudolph et al., Annu Rev Immunol 2006
• Reactome Reaction: B2M → CD8A (indirect_complex) Kjer-Nielsen et al., Proc Natl Acad Sci U S A 2004, Arnett et al., Proc Natl Acad Sci U S A 2004, Rudolph et al., Annu Rev Immunol 2006

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: B2M — CD8A Gao et al., Nature 1997*
• IRef Bind_translation Interaction: B2M — CD8A (x-ray crystallography) Gao et al., Nature 1997*

Text-mined interactions from Literome

Cheuk et al., J Immunol 2002 : Expression of each HLA ( hyb ) molecule and HLA-B27 ( nat ) /human beta(2)-microglobulin led to peripheral CD8 ( + ) T cell levels comparable with that for mice expressing a single H2-K ( b ) or H2-D ( b ) gene
Naji et al., Blood 2007 : CD3+CD4low and CD3+CD8low are induced by HLA-G : novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance ... In addition, these HLA-G induced CD3 ( + ) CD4 ( low ) and CD3 ( + ) CD8 ( low ) subpopulations are Foxp3 negative suppressor T cells whose function involves IL-10
Schenk et al., Am J Transplant 2009 : Donor-reactive CD8 memory T-cell infiltration, proliferation and ICOS expression are regulated by donor class I MHC molecule expression
Tewalt et al., PLoS Pathog 2009 : Virus-specific CD8 ( + ) T cells ( T ( CD8+ ) ) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells ( pAPC )
Takada et al., J Exp Med 2009 : However, distinct from this effect, class I MHC deprivation also enhanced naive CD8 T cell responsiveness to low-affinity ( but not high-affinity ) peptide-MHC ligands
Guehler et al., Gastroenterology 1999 : These results suggest that CD8 ( + ) TCR gamma delta IELs do not require class I MHC for development but support the notion that antigens presented by class I MHC molecules are involved in the peripheral expansion and differentiation of this subset